Results of a clinical trial to compare two competing oral antifungal treatments for toenail infection.
A data frame with 1908 observations on the following 5 variables.
a unique identifier for each patient in the trial.
degree of separation of the nail plate from the nail bed (onycholysis).
a factor with levels
the time in month when the visit actually took place.
number of visit attended.
De Backer et al. (1998) describe a clinical trial to compare two competing oral antifungal
treatments for toenail infection (dermatophyte onychomycosis). A total of 378 patients
were randomly allocated into two treatment groups, one group receiving 250mg per
day of terbinafine and the other group 200mg per day of itraconazole.
Patients were evaluated at seven visits, intended to be at weeks
0, 4, 8, 12, 24, 36, and 48 for the degree of separation of the nail
plate from the nail bed (onycholysis) dichotomized into
moderate or severe
none or mild. But patients did not always arrive exactly at the
scheduled time and the exact time in months that they did attend was recorded.
The data is not balanced since not all patients attended for all seven planned
M. D. Backer and C. D. Vroey and E. Lesaffre and I. Scheys and P. D. Keyser (1998), Twelve weeks of continuous oral therapy for toenail onychomycosis caused by dermatophytes: A double-blind comparative trial of terbinafine 250 mg/day versus itraconazole 200 mg/day. Journal of the American Academy of Dermatology, 38, S57–S63.
data("toenail", package = "HSAUR3")
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