hapiAssemble: Consensus haplotype assembly

In Hapi: Inference of Chromosome-Length Haplotypes Using Genomic Data of Single Gamete Cells

Description

Assemble the consensus high-resolution haplotypes

Usage

hapiAssemble(gmt, draftHap, keepLowConsistency = TRUE,
  consistencyThresh = 0.85)

Arguments

gmt	a dataframe of genotype data of gamete cells
draftHap	a dataframe with draft haplotype information
keepLowConsistency	logical, if low-consistent gamete cells should be kept
consistencyThresh	a numeric value of the threshold determining low-consistent gamete cells compared with the draft haplotype. Default is 0.85

Value

a dataframe containing phased haplotypes

Author(s)

Ruidong Li

Examples

finalDraft <- rep(0,500)
names(finalDraft) <- seq_len(500)

ref <- rep(0,500)
alt <- rep(1,500)

gmtDa <- data.frame(gmt1=ref, gmt2=alt, gmt3=ref,
gmt4=ref, gmt5=c(alt[1:250], ref[251:500]),
stringsAsFactors = FALSE)

idx1 <- sort(sample(seq_len(500), 30, replace = FALSE))
idx2 <- sort(sample(seq_len(500), 30, replace = FALSE))
idx3 <- sort(sample(seq_len(500), 30, replace = FALSE))

gmtDa[idx1,1] <- NA
gmtDa[idx2,2] <- NA
gmtDa[idx3,3] <- NA

consensusHap <- hapiAssemble(draftHap = finalDraft, gmt = gmtDa)

Hapi documentation built on May 2, 2019, 6:52 a.m.