Dose-response microarray example data

Description

This dose-response microarray data contains 1000 genes and 6 doses (0=control, 0.01, 0.04, 0.16, 0.63, 2.5mg/kg) with 4-5 arrays at each dose level.

Usage

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Format

An ExpressionSet object, the assayData has 1000 features and 26 samples, and in phenoData contains information of sample names and dose levels.

For the gene expression matrix obtained using the expres function, the column names are (X1, X2, ..., X26). These correspond to the dose levels (obtained using pData function): 0, 0, 0.01, 0.01, 0.04, 0.04, 0.16, 0.16, 0.63, 0.63, 2.50, 2.50, 0, 0, 0, 0.01, 0.01, 0.01, 0.04, 0.04, 0.16, 0.16, 0.63, 0.63, 2.50, 2.50.

References

Testing for Trend in Dose-Response Microarray Experiments: a Comparison of Testing Procedures, Multiplicity, and Resampling-Based Inference, Lin et al. 2007, Stat. App. in Gen. & Mol. Bio., 6(1), article 26.

Gene Expression Studies Using Affymetrix Microarrays, Goehlmann, H. and Talloen, W., Chapman & Hall/CRC, 2009

Examples

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data(dopamine)
require(Biobase)
express <- data.frame(exprs(dopamine))
dose <- unlist(pData(dopamine))
IsoPlot(dose,express[56,],type="continuous", add.curve=TRUE)