The function calculates the values for the five test statistics (the global likelihood test, Williams, Marcus, M, and the modified M) for testing increasing and decreasing alternatives.

1 | ```
IsoGene1(x, y)
``` |

`x` |
indicates the dose levels |

`y` |
is the gene expression for one gene |

A list with components

`E2.up` |
the test statistic of the global likelihood test for testing increasing alternative. |

`Williams.up` |
the test statistic of Williams for testing increasing alternative. |

`Marcus.up ` |
the test statistic of Marcus for testing increasing alternative. |

`M.up ` |
the M test statistic for testing increasing alternative. |

`ModM.up ` |
the test statistic of the modified M for testing increasing alternative. |

`E2.dn ` |
the test statistic of Williams for testing decreasing alternative. |

`Williams.dn ` |
the test statistic of global likelihood test for testing decreasing alternative. |

`Marcus.dn ` |
the test statistic of Williams for testing decreasing alternative. |

`M.dn` |
the test statistic of global likelihood test for testing decreasing alternative. |

`ModM.dn` |
the test statistic of Williams for testing increasing alternative. |

`direction` |
the direction with the higher likelihood of increasing (indicated by "u") or decreasing (indicated by "d") trend. |

This function calculates the five test statistics for both increasing and decreasing ordered alternatives for a single gene.

Lin et al.

Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R, Lin D., Shkedy Z., Yekutieli D., Amaratunga D., and Bijnens, L. (editors), (2012), Springer.

Testing for Trend in Dose-Response Microarray Experiments: a Comparison of Testing Procedures, Multiplicity, and Resampling-Based Inference, Lin et al. 2007, Stat. App. in Gen. & Mol. Bio., 6(1), article 26.

IsoGene: An R Package for Analyzing Dose-response Studies in Microarray Experiments, Pramana S., Lin D., Haldermans P., Shkedy Z., Verbeke T., De Bondt A., Talloen W., Goehlmann H., Bijnens L. 2010, R Journal 2/1.

1 2 3 4 |

Questions? Problems? Suggestions? Tweet to @rdrrHQ or email at ian@mutexlabs.com.

Please suggest features or report bugs with the GitHub issue tracker.

All documentation is copyright its authors; we didn't write any of that.