Description Usage Arguments Value Note Author(s) References See Also Examples

The function calculates the values for the five test statistics (the global likelihood test, Williams, Marcus, M, and the modified M) for testing increasing and decreasing alternatives.

1 | ```
IsoGene1(x, y)
``` |

`x` |
indicates the dose levels |

`y` |
is the gene expression for one gene |

A list with components

`E2.up` |
the test statistic of the global likelihood test for testing increasing alternative. |

`Williams.up` |
the test statistic of Williams for testing increasing alternative. |

`Marcus.up ` |
the test statistic of Marcus for testing increasing alternative. |

`M.up ` |
the M test statistic for testing increasing alternative. |

`ModM.up ` |
the test statistic of the modified M for testing increasing alternative. |

`E2.dn ` |
the test statistic of Williams for testing decreasing alternative. |

`Williams.dn ` |
the test statistic of global likelihood test for testing decreasing alternative. |

`Marcus.dn ` |
the test statistic of Williams for testing decreasing alternative. |

`M.dn` |
the test statistic of global likelihood test for testing decreasing alternative. |

`ModM.dn` |
the test statistic of Williams for testing increasing alternative. |

`direction` |
the direction with the higher likelihood of increasing (indicated by "u") or decreasing (indicated by "d") trend. |

This function calculates the five test statistics for both increasing and decreasing ordered alternatives for a single gene.

Lin et al.

Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R, Lin D., Shkedy Z., Yekutieli D., Amaratunga D., and Bijnens, L. (editors), (2012), Springer.

Testing for Trend in Dose-Response Microarray Experiments: a Comparison of Testing Procedures, Multiplicity, and Resampling-Based Inference, Lin et al. 2007, Stat. App. in Gen. & Mol. Bio., 6(1), article 26.

IsoGene: An R Package for Analyzing Dose-response Studies in Microarray Experiments, Pramana S., Lin D., Haldermans P., Shkedy Z., Verbeke T., De Bondt A., Talloen W., Goehlmann H., Bijnens L. 2010, R Journal 2/1.

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