# Plot of p-values from permutations under increasing or decreasing alternatives

### Description

The function calculates the p-values using permutations under increasing
and decreasing ordered alternatives for one gene. The p-values (*p^up* and
*p^down*) are obtained from the plot of null distribution and observed statistics.

### Usage

1 | ```
IsopvaluePlot(x, y, niter, stat = c("E2", "Williams", "Marcus", "M", "ModifM"))
``` |

### Arguments

`x` |
the dose levels |

`y` |
the gene expressions |

`niter` |
the number of permutations to use |

`stat` |
choose one of the five test statistics to use |

### Value

Plots of the null distribution and the observed test statistic under increasing and decreasing ordered alternatives.

### Note

The function obtains the p-values under increasing and decreasing ordered alternatives for a single gene.

### Author(s)

Lin et al.

### References

Lin D., Shkedy Z., Yekutieli D., Amaratunga D., and Bijnens, L. (editors). (2012) Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R. Springer.

IsoGene: An R Package for Analyzing Dose-response Studies in Microarray Experiments, Pramana S., Lin D., Haldermans P., Shkedy Z., Verbeke T., De Bondt A., Talloen W., Goehlmann H., Bijnens L. 2010, R Journal 2/1.

### See Also

`IsoGene1`

### Examples

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