LEANR: Finds "Local Subnetworks" Within an Interaction Network which Show Enrichment for Differentially Expressed Genes
Version 1.4.9

Implements the method described in "Network-based analysis of omics data: The LEAN method" [Gwinner Boulday (2016) ] Given a protein interaction network and a list of p-values describing a measure of interest (as e.g. differential gene expression) this method computes an enrichment p-value for the protein neighborhood of each gene and compares it to a background distribution of randomly drawn p-values. The resulting scores are corrected for multiple testing and significant hits are returned in tabular format.

Package details

AuthorFrederik Gwinner
Date of publication2016-11-12 15:47:01
MaintainerFrederik Gwinner <[email protected]>
Package repositoryView on CRAN
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LEANR documentation built on May 30, 2017, 7:52 a.m.