Constructs genotype x environment interaction (GxE) models where G is a weighted sum of genetic variants (genetic score) and E is a weighted sum of environments (environmental score) using the alternating optimization algorithm by JolicoeurMartineau et al. (2017) <arXiv:1703.08111>. This approach has greatly enhanced predictive power over traditional GxE models which include only a single genetic variant and a single environmental exposure. Although this approach was originally made for GxE modelling, it is flexible and does not require the use of genetic and environmental variables. It can also handle more than 2 latent variables (rather than just G and E) and 3way interactions or more. The LEGIT model produces highly interpretable results and is very parameterefficient thus it can even be used with small sample sizes (n < 250). Tools to determine the type of interaction (vantage sensitivity, diathesisstress or differential susceptibility), with any number of genetic variants or environments, are available <arXiv:1712.04058>.
Package details 


Author  Alexia JolicoeurMartineau <[email protected]> 
Maintainer  Alexia JolicoeurMartineau <[email protected]> 
License  GPL3 
Version  1.2.2 
Package repository  View on CRAN 
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