Description Usage Arguments Details Value Note References
Poly-3- adjusted point and variance estimates for long term carcinogenicity data
1 |
time |
a numeric vector of times of death of the individuals |
status |
a logical (or numeric, consisting of 0,1 only) vector giving the tumour status at time of death of each individual, where TRUE (1) = tumour present, FALSE (0) = no tumour present |
tmax |
a single numeric vector, the final time of the trial |
method |
a single charcter string, specifying the method for adjustment, with options: "BP" (Bailer Portier: assuming poly-3-adjusted rates are binomial variables), "BW" (Bieler, Williams: delta method as in Bieler-Williams (1993)) "ADD1" (as Bailer Portier, including an add1-adjustment on the raw tumour rates) "ADD2" (as Bailer Portier, including an add2-adjustment on the raw tumour rates following Agresti Caffo (2000) for binomials) |
k |
a single numeric value, the exponent to calculate survival adjusted proportions according to Bailer and Portier (1988), defaults to 3 |
Only for internal use of poly3test and poly3ci.
A list containing:
Y |
number of tumours |
n |
number of individuals |
estimate |
poly-3-adjusted rates according to Bailer, Portier (1988) |
weight |
a vector of poly-3-adjusted weights, of length n |
estp |
poly-3-adjusted rate (according to method) |
nadj |
adjusted n (sum of weights) |
varp |
variance estimate (according to method) |
varcor |
variance estimate, if necessary corrected such that estimates of 0 can not occur |
Please note, that appropriateness of the point estimates seriously depends on whether the assumptions in Bailer and Portier are met or not.
Bailer, J.A. and Portier, C.J. (1988): Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics 44, 417-431.
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