Description Usage Arguments Author(s) See Also Examples

This function creates a detailed summary of MCPMod simulation results in a Microsoft Word format.

1 | ```
SimulationReport(results, report_title, report_filename)
``` |

`results` |
Object of class MCPModSimulationResults created by the |

`report_title` |
Character value defining the report's title. |

`report_filename` |
Character value defining the report's filename. The report is saved in the current working directory. |

Alex Dmitrienko <admitrienko@medianainc.com>

`MCPModSimulation`

, `AnalysisReport`

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 | ```
# Simulation-based evaluation of dose-finding trials with a binary endpoint
# Endpoint type
endpoint_type = "Binary"
# Select the candidate dose-response models and initial values
# of the non-linear model parameters (linear, quadratic, exponential,
# emax, logistic and sigemax)
models = list(linear = NA,
quadratic = -0.5,
exponential = 0.3,
emax = 0.3,
logistic = c(0.5, 0.1),
sigemax = c(0.5, 5))
# One-sided Type I error rate
alpha = 0.025
# Direction of the dose-response relationship
direction = "increasing"
# Model selection criterion
model_selection = "AIC"
# The treatment effect for identifying the target dose
# (this effect is defined relative to the placebo effect)
Delta = 0.3
# Select the assumed dose-response model and values of the non-linear model parameters
sim_models = list(linear = NA,
placebo_effect = 0.2,
max_effect = seq(from = 0, to = 0.5, by = 0.1))
# Simulation parameters
sim_parameters = list(n = rep(40, 5),
doses = c(0, 0.05, 0.2, 0.6, 1),
dropout_rate = 0.05,
nsims = 1000,
go_threshold = 0.3)
# Perform an MCPMod-based simulation
results = MCPModSimulation(endpoint_type = endpoint_type,
models = models,
alpha = alpha,
direction = direction,
model_selection = model_selection,
Delta = Delta,
sim_models = sim_models,
sim_parameters = sim_parameters)
# Simple summary of the MCPMod simulation results
results
# Detailed summary of the MCPMod simulation results (remove tempfile)
SimulationReport(results,
"MCPMod simulation summary (Binary endpoint)",
tempfile("MCPMod simulation summary (Binary endpoint).docx", fileext=".docx"))
``` |

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