MedianaDesigner-package: Efficient Simulation-Based Power and Sample Size Calculations...

Description Details Author(s) References


The MedianaDesigner package provides efficient simulation-based power and sample size calculations for a broad class of late-stage clinical trials, including Phase II trials, seamless Phase II/III trials and Phase III trials:

For more information on this package, visit The technical manuals with a detailed description of the statistical methodology implemented in each module are available at Additional information and multiple case studies can be found in the online manual at


Package: MedianaDesigner
Type: Package
Version: 0.4
Date: 2021-10-15
License: GPL-3

Key functions included in the package:

The package comes with one example data set:

Multiple case studies are included in this vignette to illustrate the use of this package for designing clinical trials with data-driven design elements:


Mediana ( We would like to thank multiple individuals, including Thomas Brechenmacher (IQVIA), Douglas McNair (Gates Foundation) and Thomas Peppard (Certara), for their feedback that helped us improve the package and add new features.


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MedianaDesigner documentation built on Oct. 11, 2021, 9:10 a.m.