simulateData: OTU counts simulation

Description Usage Arguments Value Author(s) References Examples

Description

We used a phylogenetic tree of OTUs from a real throat microbiome data set, which consists of 856 OTUs after discarding singleton OTUs. Then based on a complicate statistical meodel, we generated the OTU counts for each individual to simulate the feature of real microbiome data.

Usage

1
simulateData(nSam=100, s=12, ncluster = 20, mu = 1000, size = 25) 

Arguments

nSam

Sample size, the default value is 100.

s

The indicator of informative cluster.

ncluster

Positive integer specifying the number of clusters of they phylogenetic tree.

mu

The mean of the negative binomial distribution.

size

The size of the negative binomial distribution

Value

A list object, including the informative OTU counts table and whole OTU counts table.

Author(s)

Chong Wu

References

Chong, W., Pan, W. (2015) An Adaptive Association Test for Microbiome Data, submitted.

Examples

1
2
OTU = simulateData()
OTU

Example output

Loading required package: vegan
Loading required package: permute
Loading required package: lattice
This is vegan 2.4-4
Loading required package: ape
Loading required package: aSPU
Loading required package: gee
Loading required package: MASS
Loading required package: mvtnorm
Loading required package: fields
Loading required package: spam
Loading required package: dotCall64
Loading required package: grid
Spam version 2.1-1 (2017-07-02) is loaded.
Type 'help( Spam)' or 'demo( spam)' for a short introduction 
and overview of this package.
Help for individual functions is also obtained by adding the
suffix '.spam' to the function name, e.g. 'help( chol.spam)'.

Attaching package: 'spam'

The following objects are masked from 'package:base':

    backsolve, forwardsolve

Loading required package: maps
Loading required package: matrixStats
Loading required package: cluster

Attaching package: 'cluster'

The following object is masked from 'package:maps':

    votes.repub

$informative.OTU
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41     0    0    0    0   0    0    0    0    0    0    0
42     0    0    0    0   0    0    0    0    0    0    0
43     0    0    0    0   0    0    0    0    0    0    1
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45     0    0    0    0   0    0    0    0    0    3    0
46     0    0    0    0   0    0    0    0    0    2    0
47     0    0    0    0   0    0    0    0    0    0    0
48     0    0    0    0   0    0    0    0    0    0    0
49     0    0    0    0   0    0    0    0    0    0    0
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51     0    0    0    0   0    0    0    0    0    0    0
52     0    0    0    0   0    0    0    0    0    0    0
53     0    0    0    0   0    0    0    0    0    0    0
54     5    0    0    0   0    0    0    0    0    0    0
55     0    0    0    0   0    0    0    0    1    0    0
56     0    0    0    0   0    0    0    0    0    0    0
57     0    0    0    0   0    0    0    0    0    0    0
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59     0    0    0    0   0    0    0    0    0    0    0
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61     0    0    0    0   0    0    0    0    9    0    0
62     0    0    0    0   0    0    0    0    0    0    0
63     0    0    0    0   0    0    0    0    0    0    0
64     0    0    0    0   0    0    0    0    0    0    0
65     0    0    0    0   0    0    0    0    0    0    0
66     0    0    0    0   0    0    0    0   10    1    0
67     0    0    0    0   0    0    0    0    0    1    0
68     0    0    0    0   0    0    0    0    0    0    0
69     0    0    0    0   0    0    0    0   12    0    0
70     0    0    0    0   0    0    0    0    0    0    0
71     0    0    0    0  15    0    0    0    0    0    0
72     0    0    0    0   0    0    0    0    0    0    0
73     0    0    0    0   0    0    0    0    0    0    0
74     0    0    0    0   0    0    0    0    0    0    0
75     1    0    0    0   0    0    0    0    0    1    0
76     0    0    0    0   0    0    0    0    0    0    0
77     0    0    0    1   0    0    0    0    4    0    0
78     0    0    0    0  27    0    0    0    0    0    0
79     0    0    0   60   0    0    0    0    0    0    0
80     0    0    0    0   0    5    0    0    0    0    0
81     0    0    0    0   0    0    0    0    1    0    0
82     0    0    0    0   0    0    2    0    0   18    0
83     0   22    0    0   0    0    0    0    8    0    0
84     0    0    0    0   0    0    0    0    2    0    0
85     0    0    0    0   0    0    0    0   12    0    0
86     0    0    0    0   0    0    0    0    0    0    0
87     0    0    0    0   0    0    0    0    0    0    0
88     0    0    0    0   0    0    0    0    1    7   12
89     0    0    0    0   0    0    0    0    0    2    0
90     0    0    0    0   0    0    0    0    0    0    0
91     0    0    0    0   0    0    0    0    0    0    0
92     0    0    0    0   0    0    0    0    0    0    0
93     0    0    0    0   0    0    0    0    0    0    0
94     0    0    0    0   0    0    0    0    0    0    0
95     0    0    0    0   0    0    0    0    6    0    0
96     0    0    0    0   0    0    0    0    0    0    0
97     0    2    0    0   0    0    0    0    0    0    0
98     0    0    0    0   0    0    0    0    2    0    0
99     0    0    0    0   0    0    0    0   21    1    0
100    0    0   36    0   0    0    0    0    0    0    0

MiSPU documentation built on May 1, 2019, 8:41 p.m.