Description Usage Arguments Author(s) References See Also
Set parameters controlling numerical methods for OptimDes
and np.OptimDes
1 | OptimDesControl(trace=TRUE,tol=0.01,n.int=c(1,5),aboveMin=c(1.05,1.10))
|
trace |
A logical value indicating if a
trace of the iteration
progress should be printed. Default is |
tol |
|
n.int |
A two-element vector containing the grid search interval for maximum sample size of one-arm and two-arm designs. Default is c(1, 5). |
aboveMin |
The minimization method searches by increasing order
from the single-stage
sample size until the criteria exceeds the current minimum by a
multiplicative factor of |
Bo Huang <bo.huang@pfizer.com> and Neal Thomas <neal.thomas@pfizer.com>
Huang B., Talukder E. and Thomas N. Optimal two-stage Phase II designs with long-term endpoints. Statistics in Biopharmaceutical Research, 2(1), 51–61.
Case M. D. and Morgan T. M. (2003) Design of Phase II cancer trials evaluating survival probabilities. BMC Medical Research Methodology, 3, 7.
Lin D. Y., Shen L., Ying Z. and Breslow N. E. (1996) Group seqential designs for monitoring survival probabilities. Biometrics, 52, 1033–1042.
Simon R. (1989) Optimal two-stage designs for phase II clinical trials. Controlled Clinical Trials, 10, 1–10.
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