Files in PFIM

Population Fisher Information Matrix

R/ModelParameter.R R/ModelAnalyticSteadyState.R R/PlotEvaluation.R R/Fim.R R/LogNormal.R R/MultiplicativeAlgorithm.R R/GenericMethods.R R/AdministrationConstraints.R R/Constant.R R/SamplingTimes.R R/LibraryOfPDModels.R R/ModelAnalyticBolusSteadyState.R R/ModelODE.R R/ModelBolus.R R/Combined1.R R/PGBOAlgorithm.R R/Optimization.R R/ModelODEInfusion.R R/ModelODEDoseNotInEquations.R R/ModelODEBolus.R R/LibraryOfPKPDModels.R R/Normal.R R/BayesianFim.R R/Proportional.R R/ModelAnalytic.R R/ModelODEInfusionDoseInEquations.R R/PFIM-package.R R/ModelAnalyticInfusionSteadyState.R R/PSOAlgorithm.R R/FedorovWynnAlgorithm.R R/Arm.R R/Evaluation.R R/ModelInfusion.R R/ModelODEDoseInEquations.R R/PopulationFim.R R/LibraryOfModels.R R/LibraryOfPKModels.R R/OptimizationAlgorithm.R R/PFIMProject.R R/Design.R R/SimplexAlgorithm.R R/Distribution.R R/IndividualFim.R R/Model.R R/SamplingTimeConstraints.R R/Administration.R R/ModelAnalyticBolus.R R/ModelError.R R/ModelAnalyticInfusion.R inst/doc/Example01.Rmd inst/doc/Example02.Rmd inst/doc/Example02.R inst/doc/LibraryOfModels.R inst/doc/LibraryOfModels.Rmd inst/doc/Example01.R inst/rmarkdown/templates/skeleton/template_FedorovAlgorithm.Rmd inst/rmarkdown/templates/skeleton/templateEvaluationPopulationFim.Rmd inst/rmarkdown/templates/skeleton/template_SimplexAlgorithm.Rmd inst/rmarkdown/templates/skeleton/template_PGBOAlgorithm.Rmd inst/rmarkdown/templates/skeleton/templateEvaluationBayesianFim.Rmd inst/rmarkdown/templates/skeleton/template_multiplicativeAlgorithm.Rmd inst/rmarkdown/templates/skeleton/templateEvaluationIndividualFim.Rmd inst/rmarkdown/templates/skeleton/template_evaluation.Rmd inst/rmarkdown/templates/skeleton/template_PSOAlgorithm.Rmd tests/testthat/test_PKModels-PFIM.R tests/testthat/test_PKPDModels-PFIM.R vignettes/Example01.Rmd vignettes/Example02.Rmd vignettes/LibraryOfModels.Rmd man/initialize-Distribution-method.Rd man/LibraryOfModels-class.Rd man/getDelta.Rd man/setAdministrations.Rd man/run.Rd man/getModelParameters.Rd man/getOptimalWeights.Rd man/LibraryOfPKModels.Rd man/PFIMProject-class.Rd man/isModelODE.Rd man/getContent.Rd man/EvaluateDesign.Rd man/getNumberOfArms.Rd man/setOutcome.Rd man/getOptimalFrequencies.Rd man/getAdministrationConstraint.Rd man/SamplingTimes-class.Rd man/getConditionNumberVarianceEffects.Rd man/setOutcomesEvaluation.Rd man/setArm.Rd man/setSigmaInter.Rd man/ModelInfusion-class.Rd man/getArms.Rd man/setFixedOmega.Rd man/setTimeDose.Rd man/getSamplingTimesConstraints.Rd man/getOutcome.Rd man/getOdeSolverParameters.Rd man/isDoseInEquations.Rd man/PopulationFim-class.Rd man/Optimization-class.Rd man/setNumberOfArms.Rd man/getOmega.Rd man/getFixedOmega.Rd man/Administration-class.Rd man/initialize-ModelAnalyticBolus-method.Rd man/getNumberOfParameters.Rd man/setEquationsAfterInfusion.Rd man/Combined1-class.Rd man/getModelParametersValues.Rd man/plotRSE.Rd man/getConditionNumberFixedEffects.Rd man/setOutcomesGradient.Rd man/isModelAnalytic.Rd man/plotSensitivityIndice.Rd man/plotFrequencies.Rd man/getFisherMatrix.Rd man/Arm-class.Rd man/getModelFromLibrary.Rd man/setSamplingTimes.Rd man/getDeterminant.Rd man/setInitialConditions.Rd man/setTinf.Rd man/getcError.Rd man/Model-class.Rd man/LibraryOfPKPDModels-class.Rd man/ModelAnalyticInfusionSteadyState-class.Rd man/checkValiditySamplingConstraint.Rd man/initialize-SimplexAlgorithm-method.Rd man/reportTablesModelError.Rd man/defineModelFromLibraryOfModels.Rd man/SamplingTimeConstraints-class.Rd man/getEquationsDuringInfusion.Rd man/setDerivatives.Rd man/Design-class.Rd man/initialize-AdministrationConstraints-method.Rd man/Distribution-class.Rd man/setDescription.Rd man/getSamplingTimes.Rd man/getDataForArmEvaluation.Rd man/PGBOAlgorithm-class.Rd man/setSamplingConstraintForOptimization.Rd man/setFixedMu.Rd man/ModelAnalyticBolus-class.Rd man/initialize-LibraryOfModels-method.Rd man/Report.Rd man/initialize-PFIMProject-method.Rd man/setEquation.Rd man/setSamplings.Rd man/Proportional-class.Rd man/getOutcomes.Rd man/EvaluateVarianceFIM.Rd man/initialize-OptimizationAlgorithm-method.Rd man/getAdministrations.Rd man/setEvaluationInitialDesignResults.Rd man/setArms.Rd man/getElementaryProtocols.Rd man/initialize-ModelAnalytic-method.Rd man/initialize-MultiplicativeAlgorithm-method.Rd man/generateFimsFromConstraints.Rd man/getDesigns.Rd man/EvaluateModelGradient.Rd man/ModelAnalyticSteadyState-class.Rd man/setOptimizationResults.Rd man/generateReportOptimization.Rd man/setFimTypeToString.Rd man/getOptimalDesign.Rd man/plotWeights.Rd man/getAdjustedGradient.Rd man/optimize.Rd man/setParameters.Rd man/setOdeSolverParameters.Rd man/reportTablesFIM.Rd man/initialize-PGBOAlgorithm-method.Rd man/setOutcomesForEvaluation.Rd man/getNumberOfIterations.Rd man/getOptimizerParameters.Rd man/PSOAlgorithm-class.Rd man/getDerivatives.Rd man/EvaluateErrorModelDerivatives.Rd man/Evaluation-class.Rd man/getDescription.Rd man/initialize-LogNormal-method.Rd man/setModelError.Rd man/getTinf.Rd man/getEvaluationFIMResults.Rd man/checkSamplingTimeConstraintsForContinuousOptimization.Rd man/getProportionsOfSubjects.Rd man/initialize-Arm-method.Rd man/initialize-Proportional-method.Rd man/getPKModel.Rd man/reportTablesPlot.Rd man/getModelEquations.Rd man/reportTablesSamplingConstraints.Rd man/setDataForArmEvaluation.Rd man/ModelODE-class.Rd man/Constant-class.Rd man/getSamplingTime.Rd man/getModel.Rd man/initialize-SamplingTimes-method.Rd man/convertPKModelAnalyticToPKModelODE.Rd man/ModelODEInfusion-class.Rd man/getCorrelationMatrix.Rd man/initialize-FedorovWynnAlgorithm-method.Rd man/reportTablesAdministration.Rd man/initialize-ModelAnalyticInfusionSteadyState-method.Rd man/getDistribution.Rd man/plotOutcomesEvaluation.Rd man/getDataFrameResults.Rd man/LibraryOfPDModels.Rd man/getInitialConditions.Rd man/setDataForModelEvaluation.Rd man/getRSE.Rd man/setContent.Rd man/getLibraryPDModels.Rd man/Normal-class.Rd man/setDesigns.Rd man/initialize-Combined1-method.Rd man/OptimizationAlgorithm-class.Rd man/setSamplingTime.Rd man/setMu.Rd man/getOptimizationResults.Rd man/AdministrationConstraints-class.Rd man/PFIM-package.Rd man/generateReportEvaluation.Rd man/initialize-Design-method.Rd man/getIterationAndCriteria.Rd man/ModelAnalytic-class.Rd man/plotEvaluation.Rd man/generateSamplingsFromSamplingConstraints.Rd man/getFim.Rd man/ModelAnalyticInfusion-class.Rd man/initialize-ModelError-method.Rd man/PlotEvaluation-class.Rd man/setShrinkage.Rd man/setOptimalWeights.Rd man/getDose.Rd man/ModelODEDoseInEquations-class.Rd man/LogNormal-class.Rd man/setSigmaSlope.Rd man/EvaluateArm.Rd man/isModelSteadyState.Rd man/getColumnAndParametersNamesFIM.Rd man/getParameters.Rd man/setSamplingTimesConstraints.Rd man/getColumnAndParametersNamesFIMInLatex.Rd man/setIterationAndCriteria.Rd man/setEquationsDuringInfusion.Rd man/getVariables.Rd man/Fim-class.Rd man/setFisherMatrix.Rd man/getNumberOfsamplingsOptimisable.Rd man/MultiplicativeAlgorithm_Rcpp.Rd man/initialize-LibraryOfPKPDModels-method.Rd man/getPDModel.Rd man/defineModelEquationsFromStringToFunction.Rd man/getModelErrorParametersValues.Rd man/EvaluateVarianceModel.Rd man/ModelError-class.Rd man/generateTables.Rd man/resizeFisherMatrix.Rd man/getOutcomesGradient.Rd man/computeVMat.Rd man/getLambda.Rd man/initialize-ModelAnalyticInfusion-method.Rd man/plotShrinkage.Rd man/getMu.Rd man/EvaluateFisherMatrix.Rd man/ModelParameter-class.Rd man/getWeightThreshold.Rd man/addModels.Rd man/parametersForComputingGradient.Rd man/setModelFromLibrary.Rd man/getNames.Rd man/IndividualFim-class.Rd man/setDose.Rd man/reportTablesModelParameters.Rd man/ModelODEDoseNotInEquations-class.Rd man/getOutcomesForEvaluation.Rd man/isModelInfusion.Rd man/getSize.Rd man/SimplexAlgorithm-class.Rd man/getSE.Rd man/setFixedEffects.Rd man/getSamplingsWindows.Rd man/setDistribution.Rd man/FedorovWynnAlgorithm_Rcpp.Rd man/getTau.Rd man/setTau.Rd man/ModelODEInfusionDoseInEquations-class.Rd man/getFixedMu.Rd man/initialize-ModelInfusion-method.Rd man/getFixedEffects.Rd man/initialize-PSOAlgorithm-method.Rd man/setName.Rd man/fun.amoeba.Rd man/getVarianceEffects.Rd man/setcError.Rd man/initialize-ModelParameter-method.Rd man/plotSE.Rd man/initialize-Constant-method.Rd man/initialize-Normal-method.Rd man/getName.Rd man/getEquationsAfterInfusion.Rd man/initialize-Evaluation-method.Rd man/getEquations.Rd man/getFixedParameters.Rd man/getShrinkage.Rd man/getModelError.Rd man/setFim.Rd man/getSamplings.Rd man/getOutcomesEvaluation.Rd man/getSigmaInter.Rd man/isModelBolus.Rd man/show.Rd man/getPKPDModel.Rd man/getSigmaSlope.Rd man/ModelBolus-class.Rd man/getFixedTimes.Rd man/defineModelUserDefined.Rd man/plotOutcomesGradient.Rd man/definePKPDModel.Rd man/setOutcomes.Rd man/setModel.Rd man/defineModel.Rd man/getAdministration.Rd man/FedorovWynnAlgorithm-class.Rd man/initialize-Model-method.Rd man/getDcriterion.Rd man/getSamplingTimeConstraint.Rd man/addModel.Rd man/initialize-SamplingTimeConstraints-method.Rd man/setVarianceEffects.Rd man/definePKModel.Rd man/initialize-ModelBolus-method.Rd man/setEvaluationFIMResults.Rd man/initialize-Fim-method.Rd man/BayesianFim-class.Rd man/initialize-ModelAnalyticBolusSteadyState-method.Rd man/fisher.simplex.Rd man/getAdministrationsConstraints.Rd man/EvaluateModel.Rd man/getTimeDose.Rd man/dataForArmEvaluation.Rd man/getOptimizer.Rd man/setEquations.Rd man/ModelAnalyticBolusSteadyState-class.Rd man/getEvaluationInitialDesignResults.Rd man/initialize-Administration-method.Rd man/defineModelType.Rd man/getNumberOfTimesByWindows.Rd man/setSize.Rd man/MultiplicativeAlgorithm-class.Rd man/getEquation.Rd man/getLibraryPKModels.Rd man/initialize-Optimization-method.Rd man/initialize-ModelAnalyticSteadyState-method.Rd man/getMinSampling.Rd man/getPlotOptions.Rd man/getEigenValues.Rd man/setOmega.Rd man/reportTablesDesign.Rd man/setOptimalDesign.Rd