PopED: Population (and Individual) Optimal Experimental Design
Version 0.3.2

Optimal experimental designs for both population and individual studies based on nonlinear mixed-effect models. Often this is based on a computation of the Fisher Information Matrix. This package was developed for pharmacometric problems, and examples and predefined models are available for these types of systems.

Browse man pages Browse package API and functions Browse package files

AuthorAndrew C. Hooker [aut, cre, trl, cph], Sebastian Ueckert [aut] (MATLAB version), Marco Foracchia [aut] (O-Matrix version), Joakim Nyberg [aut] (MATLAB version), Eric Stroemberg [ctb] (MATLAB version)
Date of publication2016-12-12 18:16:19
MaintainerAndrew C. Hooker <andrew.hooker@farmbio.uu.se>
LicenseLGPL (>= 3)
Version0.3.2
URL http://poped.sourceforge.net
Package repositoryView on CRAN
InstallationInstall the latest version of this package by entering the following in R:
install.packages("PopED")

Man pages

a_line_search: Optimize using line search
bfgsb_min: Nonlinear minimization using BFGS with box constraints
blockexp: Summarize your experiment for optimization routines
blockfinal: Result function for optimization routines
blockheader: Header function for optimization routines
blockopt: Summarize your optimization settings for optimization...
calc_autofocus: Compute the autofocus portion of the stochastic gradient...
calc_ofv_and_fim: Calculate the Fisher Information Matrix (FIM) and the...
calc_ofv_and_grad: Compute an objective function and gradient
cell: Create a cell array (a matrix of lists)
convert_variables: Create global variables in the PopED database
create_design: Create design variables for a full description of a design.
create_design_space: Create design variables and a design space for a full...
create.poped.database: Create a PopED database
diag_matlab: Function written to match MATLAB's diag function
Doptim: D-family optimization function
downsizing_general_design: Downsize a general design to a specific design
Dtrace: Trace optimization routines
ed_laplace_ofv: Evaluate the expectation of determinant the Fisher...
ed_mftot: Evaluate the expectation of the Fisher Information Matrix...
efficiency: Compute efficiency.
evaluate_design: Evaluate a design
evaluate.e.ofv.fim: Evaluate the expectation of the Fisher Information Matrix...
evaluate.fim: Evaluate the Fisher Information Matrix (FIM)
feps.add: RUV model: Additive .
feps.add.prop: RUV model: Additive and Proportional.
feps.prop: RUV model: Proportional.
feval: MATLAB feval function
ff.PK.1.comp.oral.md.CL: Structural model: one-compartment, oral absorption, multiple...
ff.PK.1.comp.oral.md.KE: Structural model: one-compartment, oral absorption, multiple...
ff.PK.1.comp.oral.sd.CL: Structural model: one-compartment, oral absorption, single...
ff.PK.1.comp.oral.sd.KE: Structural model: one-compartment, oral absorption, single...
ff.PKPD.1.comp.oral.md.CL.imax: Structural model: one-compartment, oral absoprtion, multiple...
ff.PKPD.1.comp.sd.CL.emax: Structural model: one-compartment, single bolus IV dose,...
fileparts: MATLAB fileparts function
get_all_params: Extract all model parameters from the PopED database.
getfulld: Create a full D (between subject variability) matrix given a...
get_rse: Compute the expected parameter relative standard errors
getTruncatedNormal: Generate a random sample from a truncated normal...
get_unfixed_params: Return all the unfixed parameters
gradf_eps: Model linearization with respect to epsilon.
inv: Compute the inverse of a matrix
isempty: Function written to match MATLAB's isempty function
isfield: Function written to match MATLAB's isfield function
LEDoptim: Optimization function for D-family, E-family and Laplace...
LinMatrixH: Model linearization with respect to epsilon.
LinMatrixL: The linearized matrix L
LinMatrixLH: Model linearization with respect to epsilon and eta.
LinMatrixL_occ: Model linearization with respect to occasion variablity...
log_prior_pdf: Compute the natural log of the PDF for the parameters in an...
mc_mean: Compute the monte-carlo mean of a function
median_hilow_poped: Wrap summary functions from Hmisc and ggplot to work with...
mf: The full Fisher Information Matrix (FIM) for one individual
mf3: The reduced Fisher Information Matrix (FIM) for one...
mf5: The reduced Fisher Information Matrix (FIM) for one...
mf6: The full Fisher Information Matrix (FIM) for one individual...
mf7: The full Fisher Information Matrix (FIM) for one individual...
mf8: The reduced Fisher Information Matrix (FIM) for one...
mfea: Modified Federov Exchange Algorithm
mftot: Evaluate the Fisher Information Matrix (FIM)
mftot0: The full Fisher Information Matrix (FIM)
mftot1: The reduced Fisher Information Matrix (FIM)
mftot2: The Fisher Information Matrix (FIM) using weighted models
mftot3: The Fisher Information Matrix (FIM) some other method
mftot4: The reduced Fisher Information Matrix (FIM) using the SD of...
mftot5: The full Fisher Information Matrix (FIM) parameterized with...
mftot6: The full Fisher Information Matrix (FIM) Calculating one...
mftot7: The reduced Fisher Information Matrix (FIM) parameterized...
model_prediction: Model predictions
ofv_criterion: Normalize an objective function by the size of the FIM matrix
ofv_fim: Evaluate a criterion of the Fisher Information Matrix (FIM)
ones: Creates a matrix of ones
optim_ARS: Optimization Using Adaptive Random Search.
optim_LS: Optimization Using a Line Search Algorithm.
pargen: Parameter simulation
plot_efficiency_of_windows: Plot the efficiency of windows
plot_model_prediction: Plot model predictions
PopED: PopED - *Pop*ulation (and individual) optimal *E*xperimental...
poped.choose: Choose between 'arg1' and 'arg2'
poped_gui: Run the graphical interface for PopED
poped_optim: Optimization main module for PopED
poped_optimize: Optimization main module for PopED
rand: Function written to match MATLAB's rand function
randn: Function written to match MATLAB's randn function
randperm: Function written to match MATLAB's randperm function
RS_opt: Optimize the objective function using an adaptive random...
RS_opt_gen: Optimize the objective function using an adaptive random...
size: Function written to match MATLAB's size function
start_parallel: Start parallel computational processes
summary.poped_optim: Display a summary of output from poped_optim
test_for_max: Test if any matrix element is above a max value.
test_for_min: Test if any matrix element is above a minimum value.
test_for_zeros: Test if any matrix element is zero.
test_mat_size: Test to make sure that matricies are the right size
tic: Timer function (as in MATLAB)
toc: Timer function (as in MATLAB)
zeros: Creates a matrix of zeros.

Functions

Doptim Man page Source code
Dtrace Man page Source code
LEDoptim Man page Source code
LinMatrixH Man page Source code
LinMatrixL Man page Source code
LinMatrixLH Man page Source code
LinMatrixL_occ Man page Source code
PopED Man page
PopED-package Man page
RS_opt Man page Source code
RS_opt_gen Man page Source code
a_line_search Man page Source code
bfgsb_min Man page Source code
blockexp Man page Source code
blockfinal Man page Source code
blockheader Man page Source code
blockopt Man page Source code
blockoptwrt Source code
blockother Source code
build_sfg Source code
calc_autofocus Man page Source code
calc_k Source code
calc_ofv_and_fim Man page Source code
calc_ofv_and_grad Man page Source code
cauchy_point Source code
cell Man page Source code
compute_step Source code
convert_variables Man page Source code
create.poped.database Man page Source code
create_design Man page Source code
create_design_space Man page Source code
d2fimdalpha2 Source code
datestr_poped Source code
dfimdalpha Source code
diag_matlab Man page Source code
downsizing_general_design Man page Source code
ed_laplace_ofv Man page Source code
ed_mftot Man page Source code
efficiency Man page Source code
evaluate.e.ofv.fim Man page Source code
evaluate.fim Man page Source code
evaluate_design Man page Source code
feps.add Man page Source code
feps.add.prop Man page Source code
feps.prop Man page Source code
feval Man page Source code
ff.PK.1.comp.oral.md.CL Man page Source code
ff.PK.1.comp.oral.md.KE Man page Source code
ff.PK.1.comp.oral.sd.CL Man page Source code
ff.PK.1.comp.oral.sd.KE Man page Source code
ff.PKPD.1.comp.oral.md.CL.imax Man page Source code
ff.PKPD.1.comp.sd.CL.emax Man page Source code
fileparts Man page Source code
find.largest.index Source code
find_matlab Source code
fprintf Source code
fullfile Source code
getTruncatedNormal Man page Source code
get_all_params Man page Source code
get_cov_matrix_index Source code
get_cv Source code
get_discrete_val Source code Source code
get_discrete_x Source code
get_fim_size Source code
get_parnam Source code
get_rse Man page Source code
get_step_size Source code
get_unfixed_params Man page Source code
get_vector_str Source code
getfulld Man page Source code
graddetmfa Source code
graddetmfa_ext Source code
graddetmfxt Source code
graddetmfxt_ext Source code
gradf_eps Man page Source code
gradff Source code
gradfg Source code
gradfg_occ Source code
gradlndetmfa Source code
gradlndetmfa_ext Source code
gradlndetmfxt Source code
gradlndetmfxt_ext Source code
gradofv_a Source code
gradofv_xt Source code
gradtrmfa Source code
gradtrmfxt Source code
graph_det Source code
grouped_rand Source code
grouped_rand_a Source code
hessian_eta_complex Source code
hesskalpha2 Source code
ind_estimates Source code
ind_likelihood Source code
inv Man page Source code
isempty Man page Source code
isfield Man page Source code
isinf Source code
isnan Source code
kron_tmp Source code
limit_value Source code
line_search Source code
line_search_uc Source code
linspace Source code
log_prior_pdf Man page Source code
m1 Source code
m2 Source code
m3 Source code
m4 Source code
matrix_all Source code
matrix_any Source code
mc_mean Man page Source code
median_hilow_poped Man page Source code
mf Man page Source code
mf3 Man page Source code
mf5 Man page Source code
mf6 Man page Source code
mf7 Man page Source code
mf8 Man page Source code
mf_all Source code
mfea Man page Source code
mftot Man page Source code
mftot0 Man page Source code
mftot1 Man page Source code
mftot2 Man page Source code
mftot3 Man page Source code
mftot4 Man page Source code
mftot5 Man page Source code
mftot6 Man page Source code
mftot7 Man page Source code
min_function Source code
model_prediction Man page Source code
new_ferror_file Source code
numel Source code
ofv_criterion Man page Source code
ofv_fim Man page Source code
ones Man page Source code
optim_ARS Man page Source code
optim_LS Man page Source code
pargen Man page Source code
plot_efficiency_of_windows Man page Source code
plot_model_prediction Man page Source code
poped Man page
poped.choose Man page Source code
poped_gui Man page Source code
poped_optim Man page Source code
poped_optimize Man page Source code
print_information Source code
print_params Source code
print_xt Source code
projected_gradient_norm Source code
rand Man page Source code
randn Man page Source code
randperm Man page Source code
rem Source code
reshape_matlab Source code
sg_search Source code
size Man page Source code
start_parallel Man page Source code
subspace_min Source code
summary.poped_optim Man page Source code
test_for_max Man page Source code
test_for_min Man page Source code
test_for_zeros Man page Source code
test_mat_size Man page Source code
tic Man page Source code
toc Man page Source code
trace_matrix Source code
tryCatch.W.E Source code
update_designinlist Source code
update_offdiag Source code
v Source code
write_iterationfile Source code
write_matrix Source code
writet Source code
zeros Man page Source code

Files

inst
inst/examples
inst/examples/ex.1.b.PK.1.comp.oral.md.re-parameterize.R
inst/examples/two_comp_oral_CL.c
inst/examples/ex.9.PK.2.comp.oral.md.ode.compiled.R
inst/examples/ex.10.PKPD.HCV.compiled.R
inst/examples/ex.7.PK.1.comp.maturation.R
inst/examples/ex.1.c.PK.1.comp.oral.md.ODE.compiled.R
inst/examples/ex.1.a.PK.1.comp.oral.md.intro.R
inst/examples/ex.8.tmdd_qss_one_target_compiled.R
inst/examples/ex.2.a.warfarin.evaluate.R
inst/examples/ex.3.b.PKPD.1.comp.oral.md.imax.ED-opt.R
inst/examples/ex.4.PKPD.1.comp.emax.R
inst/examples/ex.2.e.warfarin.Ds.R
inst/examples/ex.2.b.warfarin.optimize.R
inst/examples/ex.6.PK.1.comp.oral.sd.R
inst/examples/ex.2.c.warfarin.ODE.compiled.R
inst/examples/ex.5.PD.emax.hill.R
inst/examples/ex.2.d.warfarin.ED.R
inst/examples/tmdd_qss_one_target.c
inst/examples/one_comp_oral_CL.c
inst/examples/HCV_ode.c
inst/examples/ex.3.a.PKPD.1.comp.oral.md.imax.D-opt.R
inst/CITATION
inst/doc
inst/doc/intro-poped.html
inst/doc/intro-poped.Rmd
inst/doc/intro-poped.R
inst/shinyapp
inst/shinyapp/ui.R
inst/shinyapp/server.R
inst/shinyapp/www
inst/shinyapp/www/poped_splash.png
tests
tests/testthat.R
tests/testthat
tests/testthat/PopED_output_summary_mfea_opt_1.txt
tests/testthat/PopED_output_summary_D_cont_opt_1.txt
tests/testthat/examples_fcn_doc
tests/testthat/examples_fcn_doc/examples_mftot.R
tests/testthat/examples_fcn_doc/examples_RS_opt_gen.R
tests/testthat/examples_fcn_doc/examples_ed_mftot.R
tests/testthat/examples_fcn_doc/warfarin_ed.R
tests/testthat/examples_fcn_doc/examples_rand.R
tests/testthat/examples_fcn_doc/examples_feps.add.R
tests/testthat/examples_fcn_doc/examples_ff.PK.1.comp.oral.sd.CL.R
tests/testthat/examples_fcn_doc/examples_LEDoptim.R
tests/testthat/examples_fcn_doc/examples_blockfinal.R
tests/testthat/examples_fcn_doc/examples_RS_opt.R
tests/testthat/examples_fcn_doc/examples_zeros.R
tests/testthat/examples_fcn_doc/examples_ff.PKPD.1.comp.oral.md.CL.imax.R
tests/testthat/examples_fcn_doc/examples_mftot0.R
tests/testthat/examples_fcn_doc/examples_a_line_search.R
tests/testthat/examples_fcn_doc/examples_optim_ARS.R
tests/testthat/examples_fcn_doc/examples_test_mat_size.R
tests/testthat/examples_fcn_doc/examples_mf6.R
tests/testthat/examples_fcn_doc/examples_Dtrace.R
tests/testthat/examples_fcn_doc/examples_Doptim.R
tests/testthat/examples_fcn_doc/examples_ed_laplace_ofv.R
tests/testthat/examples_fcn_doc/examples_fileparts.R
tests/testthat/examples_fcn_doc/examples_test_for_zeros.R
tests/testthat/examples_fcn_doc/examples_isfield.R
tests/testthat/examples_fcn_doc/examples_ff.PK.1.comp.oral.md.KE.R
tests/testthat/examples_fcn_doc/examples_ones.R
tests/testthat/examples_fcn_doc/examples_mftot4.R
tests/testthat/examples_fcn_doc/examples_calc_ofv_and_fim.R
tests/testthat/examples_fcn_doc/examples_feval.R
tests/testthat/examples_fcn_doc/examples_getTruncatedNormal.R
tests/testthat/examples_fcn_doc/examples_mf5.R
tests/testthat/examples_fcn_doc/examples_model_prediction.R
tests/testthat/examples_fcn_doc/examples_ff.PK.1.comp.oral.sd.KE.R
tests/testthat/examples_fcn_doc/examples_diag_matlab.R
tests/testthat/examples_fcn_doc/examples_poped-package.R
tests/testthat/examples_fcn_doc/examples_ff.PK.1.comp.oral.md.CL.R
tests/testthat/examples_fcn_doc/examples_poped.choose.R
tests/testthat/examples_fcn_doc/examples_pargen.R
tests/testthat/examples_fcn_doc/examples_mftot6.R
tests/testthat/examples_fcn_doc/examples_mf7.R
tests/testthat/examples_fcn_doc/examples_mftot1.R
tests/testthat/examples_fcn_doc/examples_mfea.R
tests/testthat/examples_fcn_doc/examples_LinMatrixL.R
tests/testthat/examples_fcn_doc/examples_isempty.R
tests/testthat/examples_fcn_doc/examples_gradf_eps.R
tests/testthat/examples_fcn_doc/examples_getfulld.R
tests/testthat/examples_fcn_doc/examples_create.poped.database.R
tests/testthat/examples_fcn_doc/examples_blockopt.R
tests/testthat/examples_fcn_doc/examples_optim_LS.R
tests/testthat/examples_fcn_doc/examples_build_sfg.R
tests/testthat/examples_fcn_doc/examples_toc.R
tests/testthat/examples_fcn_doc/examples_mftot7.R
tests/testthat/examples_fcn_doc/examples_bfgsb_min.R
tests/testthat/examples_fcn_doc/examples_calc_autofocus.R
tests/testthat/examples_fcn_doc/examples_LinMatrixH.R
tests/testthat/examples_fcn_doc/examples_randperm.R
tests/testthat/examples_fcn_doc/examples_ff.PKPD.1.comp.sd.CL.emax.R
tests/testthat/examples_fcn_doc/examples_tic.R
tests/testthat/examples_fcn_doc/warfarin_optimize.R
tests/testthat/examples_fcn_doc/examples_mftot5.R
tests/testthat/examples_fcn_doc/examples_summary.poped_optim.R
tests/testthat/examples_fcn_doc/examples_mf.R
tests/testthat/examples_fcn_doc/examples_blockexp.R
tests/testthat/examples_fcn_doc/examples_mf3.R
tests/testthat/examples_fcn_doc/examples_calc_ofv_and_grad.R
tests/testthat/examples_fcn_doc/examples_create_design_space.R
tests/testthat/examples_fcn_doc/examples_evaluate.fim.R
tests/testthat/examples_fcn_doc/examples_LinMatrixLH.R
tests/testthat/examples_fcn_doc/examples_randn.R
tests/testthat/examples_fcn_doc/examples_blockheader.R
tests/testthat/examples_fcn_doc/examples_mf8.R
tests/testthat/examples_fcn_doc/examples_plot_efficiency_of_windows.R
tests/testthat/examples_fcn_doc/examples_ofv_criterion.R
tests/testthat/examples_fcn_doc/examples_poped_optim.R
tests/testthat/examples_fcn_doc/examples_poped_optimize.R
tests/testthat/examples_fcn_doc/examples_size.R
tests/testthat/examples_fcn_doc/examples_downsizing_general_design.R
tests/testthat/examples_fcn_doc/examples_test_for_max.R
tests/testthat/examples_fcn_doc/examples_evaluate.e.ofv.fim.R
tests/testthat/examples_fcn_doc/examples_LinMatrixL_occ.R
tests/testthat/examples_fcn_doc/examples_ofv_fim.R
tests/testthat/examples_fcn_doc/warfarin_basic.R
tests/testthat/examples_fcn_doc/examples_create_design.R
tests/testthat/examples_fcn_doc/examples_evaluate_design.R
tests/testthat/examples_fcn_doc/examples_test_for_min.R
tests/testthat/examples_fcn_doc/examples_cell.R
tests/testthat/examples_fcn_doc/examples_log_prior_pdf.R
tests/testthat/examples_fcn_doc/examples_plot_model_prediction.R
tests/testthat/examples_fcn_doc/examples_get_all_params.R
tests/testthat/PopED_output_summary_ED_Laplace_opt.txt
tests/testthat/PopED_output_summary_RS.txt
tests/testthat/test_evaluate.fim.R
tests/testthat/test_optimization.R
tests/testthat/helper_options.R
tests/testthat/test_E_family.R
tests/testthat/PopED_output_summary_RS_1.txt
tests/testthat/helper_functions.R
tests/testthat/test_create_databases.R
tests/testthat/test_examples.R
tests/testthat/test_distributions.R
tests/testthat/test_evaluate_design.R
tests/testthat/test_predictions.R
NAMESPACE
NEWS
R
R/mf3.R
R/mftot1.R
R/zeros.R
R/m4.R
R/mftot5.R
R/summary.poped_optim.R
R/mfea.R
R/mftot7.R
R/models.R
R/blockopt.R
R/getfulld.R
R/v.R
R/write_matrix.R
R/write_iterationfile.R
R/line_search_uc.R
R/ed_mftot.R
R/datestr_poped.R
R/mf7.R
R/gradofv_xt.R
R/trace_matrix.R
R/ones.R
R/mf_all.R
R/test_for_max.R
R/dfimdalpha.R
R/fileparts.R
R/projected_gradient_norm.R
R/size.R
R/mftot2.R
R/feval.R
R/ofv_criterion.R
R/LEDoptim.R
R/graddetmfxt.R
R/bfgsb_min.R
R/update_offdiag.R
R/graddetmfxt_ext.R
R/gradff.R
R/gradfg.R
R/kron_tmp.R
R/a_line_search.R
R/evaluate.e.ofv.fim.R
R/mc_mean.R
R/isnan.R
R/mf5.R
R/d2fimdalpha2.R
R/matrix_any.R
R/update_designinlist.R
R/get_unfixed_params.R
R/fullfile.R
R/get_all_params.R
R/start_parallel.R
R/create_design.R
R/hessian_eta_complex.R
R/calc_ofv_and_fim.R
R/RS_opt.R
R/inv.R
R/isempty.R
R/evaluate_design.R
R/get_cov_matrix_index.R
R/poped_optimize.R
R/line_search.R
R/subspace_min.R
R/test_mat_size.R
R/mftot.R
R/create.poped.database.R
R/RS_opt_gen.R
R/LinMatrixLH.R
R/Dtrace.R
R/ind_likelihood.R
R/LinMatrixL.R
R/mf8.R
R/grouped_rand.R
R/m3.R
R/blockoptwrt.R
R/graddetmfa_ext.R
R/gradlndetmfxt_ext.R
R/tic.R
R/test_for_zeros.R
R/convert_variables.R
R/gradofv_a.R
R/mftot4.R
R/graddetmfa.R
R/find_matlab.R
R/poped_optim.R
R/cell.R
R/m2.R
R/mftot0.R
R/isinf.R
R/ed_laplace_ofv.R
R/model_prediction.R
R/create_design_space.R
R/isfield.R
R/randn.R
R/LinMatrixL_occ.R
R/poped_gui.R
R/matrix_all.R
R/get_discrete_x.R
R/fprintf.R
R/toc.R
R/pargen.R
R/test_for_min.R
R/Doptim.R
R/linspace.R
R/mftot6.R
R/rem.R
R/writet.R
R/limit_value.R
R/optim_LS.R
R/median_hilow_poped.R
R/rand.R
R/PopED.R
R/blockfinal.R
R/get_vector_str.R
R/gradfg_occ.R
R/cauchy_point.R
R/blockheader.R
R/ofv_fim.R
R/mf6.R
R/get_fim_size.R
R/numel.R
R/getTruncatedNormal.R
R/build_sfg.R
R/plot_efficiency_of_windows.R
R/mftot3.R
R/blockexp.R
R/grouped_rand_a.R
R/log_prior_pdf.R
R/evaluate.fim.R
R/blockother.R
R/randperm.R
R/reshape_matlab.R
R/gradtrmfxt.R
R/hesskalpha2.R
R/gradtrmfa.R
R/mf.R
R/gradlndetmfa_ext.R
R/plot_model_prediction.R
R/get_cv.R
R/zzz.R
R/downsizing_general_design.R
R/diag_matlab.R
R/find.largest.index.R
R/LinMatrixH.R
R/gradlndetmfxt.R
R/optim_ARS.R
R/m1.R
R/gradlndetmfa.R
R/ind_estimates.R
vignettes
vignettes/intro-poped_cache
vignettes/intro-poped_cache/html
vignettes/intro-poped_cache/html/cost_optimization_f0f2d6281f61cf558abf1fc1f5bdf3c8.rdx
vignettes/intro-poped_cache/html/optimize_a2c5cd3f5dcf8a020a7e81c8d4ea906a.RData
vignettes/intro-poped_cache/html/__packages
vignettes/intro-poped_cache/html/optimize_a2c5cd3f5dcf8a020a7e81c8d4ea906a.rdx
vignettes/intro-poped_cache/html/optimize_dose_cc36fad2848e2f8b1aad976956b56449.rdx
vignettes/intro-poped_cache/html/cost_optimization_f0f2d6281f61cf558abf1fc1f5bdf3c8.RData
vignettes/intro-poped_cache/html/optimize_dose_cc36fad2848e2f8b1aad976956b56449.rdb
vignettes/intro-poped_cache/html/optimize_a2c5cd3f5dcf8a020a7e81c8d4ea906a.rdb
vignettes/intro-poped_cache/html/unnamed-chunk-10_e364407314b7746b9082627be42c8a28.rdb
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vignettes/intro-poped_cache/html/cost_optimization_f0f2d6281f61cf558abf1fc1f5bdf3c8.rdb
vignettes/intro-poped_cache/html/unnamed-chunk-10_e364407314b7746b9082627be42c8a28.rdx
vignettes/intro-poped.Rmd
vignettes/intro-poped_files
vignettes/intro-poped_files/figure-html
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README.md
MD5
build
build/vignette.rds
DESCRIPTION
man
man/Dtrace.Rd
man/isempty.Rd
man/calc_ofv_and_fim.Rd
man/create_design.Rd
man/mftot3.Rd
man/mftot5.Rd
man/mf8.Rd
man/downsizing_general_design.Rd
man/mftot2.Rd
man/calc_autofocus.Rd
man/create_design_space.Rd
man/calc_ofv_and_grad.Rd
man/LinMatrixH.Rd
man/ff.PK.1.comp.oral.md.KE.Rd
man/LinMatrixLH.Rd
man/test_for_max.Rd
man/toc.Rd
man/poped_gui.Rd
man/mftot.Rd
man/mftot1.Rd
man/ff.PKPD.1.comp.sd.CL.emax.Rd
man/convert_variables.Rd
man/ones.Rd
man/mf.Rd
man/test_for_zeros.Rd
man/plot_model_prediction.Rd
man/fileparts.Rd
man/zeros.Rd
man/optim_LS.Rd
man/rand.Rd
man/mftot0.Rd
man/feps.add.prop.Rd
man/blockheader.Rd
man/LinMatrixL.Rd
man/getfulld.Rd
man/mf3.Rd
man/ff.PK.1.comp.oral.sd.KE.Rd
man/blockexp.Rd
man/Doptim.Rd
man/poped_optimize.Rd
man/median_hilow_poped.Rd
man/model_prediction.Rd
man/LEDoptim.Rd
man/pargen.Rd
man/LinMatrixL_occ.Rd
man/test_for_min.Rd
man/tic.Rd
man/create.poped.database.Rd
man/summary.poped_optim.Rd
man/ff.PK.1.comp.oral.md.CL.Rd
man/a_line_search.Rd
man/getTruncatedNormal.Rd
man/mfea.Rd
man/ed_laplace_ofv.Rd
man/test_mat_size.Rd
man/mftot7.Rd
man/evaluate_design.Rd
man/blockopt.Rd
man/randn.Rd
man/evaluate.e.ofv.fim.Rd
man/feps.add.Rd
man/get_all_params.Rd
man/plot_efficiency_of_windows.Rd
man/mftot6.Rd
man/ff.PKPD.1.comp.oral.md.CL.imax.Rd
man/size.Rd
man/feval.Rd
man/mf6.Rd
man/isfield.Rd
man/mc_mean.Rd
man/RS_opt.Rd
man/ff.PK.1.comp.oral.sd.CL.Rd
man/mftot4.Rd
man/gradf_eps.Rd
man/optim_ARS.Rd
man/cell.Rd
man/poped.choose.Rd
man/inv.Rd
man/efficiency.Rd
man/ofv_criterion.Rd
man/start_parallel.Rd
man/get_rse.Rd
man/mf5.Rd
man/evaluate.fim.Rd
man/poped_optim.Rd
man/log_prior_pdf.Rd
man/ed_mftot.Rd
man/bfgsb_min.Rd
man/RS_opt_gen.Rd
man/get_unfixed_params.Rd
man/blockfinal.Rd
man/feps.prop.Rd
man/PopED.Rd
man/randperm.Rd
man/diag_matlab.Rd
man/mf7.Rd
man/ofv_fim.Rd
PopED documentation built on May 19, 2017, 8:01 a.m.