PopED: Population (and Individual) Optimal Experimental Design

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Optimal experimental designs for both population and individual studies based on nonlinear mixed-effect models. Often this is based on a computation of the Fisher Information Matrix. This package was developed for pharmacometric problems, and examples and predefined models are available for these types of systems.

Author
Andrew C. Hooker [aut, cre, trl, cph], Sebastian Ueckert [aut] (MATLAB version), Marco Foracchia [aut] (O-Matrix version), Joakim Nyberg [aut] (MATLAB version), Eric Stroemberg [ctb] (MATLAB version)
Date of publication
2016-10-19 13:07:11
Maintainer
Andrew C. Hooker <andrew.hooker@farmbio.uu.se>
License
LGPL (>= 3)
Version
0.3.1
URLs

View on CRAN

Man pages

a_line_search
Optimize using line search
bfgsb_min
Nonlinear minimization using BFGS with box constraints
blockexp
Summarize your experiment for optimization routines
blockfinal
Result function for optimization routines
blockheader
Header function for optimization routines
blockopt
Summarize your optimization settings for optimization...
calc_autofocus
Compute the autofocus portion of the stochastic gradient...
calc_ofv_and_fim
Calculate the Fisher Information Matrix (FIM) and the...
calc_ofv_and_grad
Compute an objective function and gradient
cell
Create a cell array (a matrix of lists)
convert_variables
Create global variables in the PopED database
create_design
Create design variables for a full description of a design.
create_design_space
Create design variables and a design space for a full...
create.poped.database
Create a PopED database
diag_matlab
Function written to match MATLAB's diag function
Doptim
D-family optimization function
downsizing_general_design
Downsize a general design to a specific design
Dtrace
Trace optimization routines
ed_laplace_ofv
Evaluate the expectation of determinant the Fisher...
ed_mftot
Evaluate the expectation of the Fisher Information Matrix...
efficiency
Compute efficiency.
evaluate_design
Evaluate a design
evaluate.e.ofv.fim
Evaluate the expectation of the Fisher Information Matrix...
evaluate.fim
Evaluate the Fisher Information Matrix (FIM)
feps.add
RUV model: Additive .
feps.add.prop
RUV model: Additive and Proportional.
feps.prop
RUV model: Proportional.
feval
MATLAB feval function
ff.PK.1.comp.oral.md.CL
Structural model: one-compartment, oral absorption, multiple...
ff.PK.1.comp.oral.md.KE
Structural model: one-compartment, oral absorption, multiple...
ff.PK.1.comp.oral.sd.CL
Structural model: one-compartment, oral absorption, single...
ff.PK.1.comp.oral.sd.KE
Structural model: one-compartment, oral absorption, single...
ff.PKPD.1.comp.oral.md.CL.imax
Structural model: one-compartment, oral absoprtion, multiple...
ff.PKPD.1.comp.sd.CL.emax
Structural model: one-compartment, single bolus IV dose,...
fileparts
MATLAB fileparts function
get_all_params
Extract all model parameters from the PopED database.
getfulld
Create a full D (between subject variability) matrix given a...
get_rse
Compute the expected parameter relative standard errors
getTruncatedNormal
Generate a random sample from a truncated normal...
get_unfixed_params
Return all the unfixed parameters
gradf_eps
Model linearization with respect to epsilon.
inv
Compute the inverse of a matrix
isempty
Function written to match MATLAB's isempty function
isfield
Function written to match MATLAB's isfield function
LEDoptim
Optimization function for D-family, E-family and Laplace...
LinMatrixH
Model linearization with respect to epsilon.
LinMatrixL
The linearized matrix L
LinMatrixLH
Model linearization with respect to epsilon and eta.
LinMatrixL_occ
Model linearization with respect to occasion variablity...
log_prior_pdf
Compute the natural log of the PDF for the parameters in an...
mc_mean
Compute the monte-carlo mean of a function
median_hilow_poped
Wrap summary functions from Hmisc and ggplot to work with...
mf
The full Fisher Information Matrix (FIM) for one individual
mf3
The reduced Fisher Information Matrix (FIM) for one...
mf5
The reduced Fisher Information Matrix (FIM) for one...
mf6
The full Fisher Information Matrix (FIM) for one individual...
mf7
The full Fisher Information Matrix (FIM) for one individual...
mf8
The reduced Fisher Information Matrix (FIM) for one...
mfea
Modified Federov Exchange Algorithm
mftot
Evaluate the Fisher Information Matrix (FIM)
mftot0
The full Fisher Information Matrix (FIM)
mftot1
The reduced Fisher Information Matrix (FIM)
mftot2
The Fisher Information Matrix (FIM) using weighted models
mftot3
The Fisher Information Matrix (FIM) some other method
mftot4
The reduced Fisher Information Matrix (FIM) using the SD of...
mftot5
The full Fisher Information Matrix (FIM) parameterized with...
mftot6
The full Fisher Information Matrix (FIM) Calculating one...
mftot7
The reduced Fisher Information Matrix (FIM) parameterized...
model_prediction
Model predictions
ofv_criterion
Normalize an objective function by the size of the FIM matrix
ofv_fim
Evaluate a criterion of the Fisher Information Matrix (FIM)
ones
Creates a matrix of ones
optim_ARS
Optimization Using Adaptive Random Search.
optim_LS
Optimization Using a Line Search Algorithm.
pargen
Parameter simulation
plot_efficiency_of_windows
Plot the efficiency of windows
plot_model_prediction
Plot model predictions
PopED
PopED - *Pop*ulation (and individual) optimal *E*xperimental...
poped.choose
Choose between 'arg1' and 'arg2'
poped_gui
Run the graphical interface for PopED
poped_optim
Optimization main module for PopED
poped_optimize
Optimization main module for PopED
rand
Function written to match MATLAB's rand function
randn
Function written to match MATLAB's randn function
randperm
Function written to match MATLAB's randperm function
RS_opt
Optimize the objective function using an adaptive random...
RS_opt_gen
Optimize the objective function using an adaptive random...
size
Function written to match MATLAB's size function
start_parallel
Start parallel computational processes
test_for_max
Test if any matrix element is above a max value.
test_for_min
Test if any matrix element is above a minimum value.
test_for_zeros
Test if any matrix element is zero.
test_mat_size
Test to make sure that matricies are the right size
tic
Timer function (as in MATLAB)
toc
Timer function (as in MATLAB)
zeros
Creates a matrix of zeros.

Files in this package

PopED
PopED/inst
PopED/inst/examples
PopED/inst/examples/ex.1.b.PK.1.comp.oral.md.re-parameterize.R
PopED/inst/examples/two_comp_oral_CL.c
PopED/inst/examples/ex.9.PK.2.comp.oral.md.ode.compiled.R
PopED/inst/examples/ex.10.PKPD.HCV.compiled.R
PopED/inst/examples/ex.7.PK.1.comp.maturation.R
PopED/inst/examples/ex.1.c.PK.1.comp.oral.md.ODE.compiled.R
PopED/inst/examples/ex.1.a.PK.1.comp.oral.md.intro.R
PopED/inst/examples/ex.8.tmdd_qss_one_target_compiled.R
PopED/inst/examples/ex.2.a.warfarin.evaluate.R
PopED/inst/examples/ex.3.b.PKPD.1.comp.oral.md.imax.ED-opt.R
PopED/inst/examples/ex.4.PKPD.1.comp.emax.R
PopED/inst/examples/ex.2.e.warfarin.Ds.R
PopED/inst/examples/ex.2.b.warfarin.optimize.R
PopED/inst/examples/ex.6.PK.1.comp.oral.sd.R
PopED/inst/examples/ex.2.c.warfarin.ODE.compiled.R
PopED/inst/examples/ex.5.PD.emax.hill.R
PopED/inst/examples/ex.2.d.warfarin.ED.R
PopED/inst/examples/tmdd_qss_one_target.c
PopED/inst/examples/one_comp_oral_CL.c
PopED/inst/examples/HCV_ode.c
PopED/inst/examples/ex.3.a.PKPD.1.comp.oral.md.imax.D-opt.R
PopED/inst/CITATION
PopED/inst/doc
PopED/inst/doc/intro-poped.html
PopED/inst/doc/intro-poped.Rmd
PopED/inst/doc/intro-poped.R
PopED/inst/shinyapp
PopED/inst/shinyapp/ui.R
PopED/inst/shinyapp/server.R
PopED/inst/shinyapp/www
PopED/inst/shinyapp/www/poped_splash.png
PopED/tests
PopED/tests/testthat.R
PopED/tests/testthat
PopED/tests/testthat/PopED_output_summary_mfea_opt_1.txt
PopED/tests/testthat/PopED_output_summary_D_cont_opt_1.txt
PopED/tests/testthat/examples_fcn_doc
PopED/tests/testthat/examples_fcn_doc/examples_mftot.R
PopED/tests/testthat/examples_fcn_doc/examples_RS_opt_gen.R
PopED/tests/testthat/examples_fcn_doc/examples_ed_mftot.R
PopED/tests/testthat/examples_fcn_doc/warfarin_ed.R
PopED/tests/testthat/examples_fcn_doc/examples_rand.R
PopED/tests/testthat/examples_fcn_doc/examples_feps.add.R
PopED/tests/testthat/examples_fcn_doc/examples_ff.PK.1.comp.oral.sd.CL.R
PopED/tests/testthat/examples_fcn_doc/examples_LEDoptim.R
PopED/tests/testthat/examples_fcn_doc/examples_blockfinal.R
PopED/tests/testthat/examples_fcn_doc/examples_RS_opt.R
PopED/tests/testthat/examples_fcn_doc/examples_zeros.R
PopED/tests/testthat/examples_fcn_doc/examples_ff.PKPD.1.comp.oral.md.CL.imax.R
PopED/tests/testthat/examples_fcn_doc/examples_mftot0.R
PopED/tests/testthat/examples_fcn_doc/examples_a_line_search.R
PopED/tests/testthat/examples_fcn_doc/examples_optim_ARS.R
PopED/tests/testthat/examples_fcn_doc/examples_test_mat_size.R
PopED/tests/testthat/examples_fcn_doc/examples_mf6.R
PopED/tests/testthat/examples_fcn_doc/examples_Dtrace.R
PopED/tests/testthat/examples_fcn_doc/examples_Doptim.R
PopED/tests/testthat/examples_fcn_doc/examples_ed_laplace_ofv.R
PopED/tests/testthat/examples_fcn_doc/examples_fileparts.R
PopED/tests/testthat/examples_fcn_doc/examples_test_for_zeros.R
PopED/tests/testthat/examples_fcn_doc/examples_isfield.R
PopED/tests/testthat/examples_fcn_doc/examples_ff.PK.1.comp.oral.md.KE.R
PopED/tests/testthat/examples_fcn_doc/examples_ones.R
PopED/tests/testthat/examples_fcn_doc/examples_mftot4.R
PopED/tests/testthat/examples_fcn_doc/examples_calc_ofv_and_fim.R
PopED/tests/testthat/examples_fcn_doc/examples_feval.R
PopED/tests/testthat/examples_fcn_doc/examples_getTruncatedNormal.R
PopED/tests/testthat/examples_fcn_doc/examples_mf5.R
PopED/tests/testthat/examples_fcn_doc/examples_model_prediction.R
PopED/tests/testthat/examples_fcn_doc/examples_ff.PK.1.comp.oral.sd.KE.R
PopED/tests/testthat/examples_fcn_doc/examples_diag_matlab.R
PopED/tests/testthat/examples_fcn_doc/examples_poped-package.R
PopED/tests/testthat/examples_fcn_doc/examples_ff.PK.1.comp.oral.md.CL.R
PopED/tests/testthat/examples_fcn_doc/examples_poped.choose.R
PopED/tests/testthat/examples_fcn_doc/examples_pargen.R
PopED/tests/testthat/examples_fcn_doc/examples_mftot6.R
PopED/tests/testthat/examples_fcn_doc/examples_mf7.R
PopED/tests/testthat/examples_fcn_doc/examples_mftot1.R
PopED/tests/testthat/examples_fcn_doc/examples_mfea.R
PopED/tests/testthat/examples_fcn_doc/examples_LinMatrixL.R
PopED/tests/testthat/examples_fcn_doc/examples_isempty.R
PopED/tests/testthat/examples_fcn_doc/examples_gradf_eps.R
PopED/tests/testthat/examples_fcn_doc/examples_getfulld.R
PopED/tests/testthat/examples_fcn_doc/examples_create.poped.database.R
PopED/tests/testthat/examples_fcn_doc/examples_blockopt.R
PopED/tests/testthat/examples_fcn_doc/examples_optim_LS.R
PopED/tests/testthat/examples_fcn_doc/examples_build_sfg.R
PopED/tests/testthat/examples_fcn_doc/examples_toc.R
PopED/tests/testthat/examples_fcn_doc/examples_mftot7.R
PopED/tests/testthat/examples_fcn_doc/examples_bfgsb_min.R
PopED/tests/testthat/examples_fcn_doc/examples_calc_autofocus.R
PopED/tests/testthat/examples_fcn_doc/examples_LinMatrixH.R
PopED/tests/testthat/examples_fcn_doc/examples_randperm.R
PopED/tests/testthat/examples_fcn_doc/examples_ff.PKPD.1.comp.sd.CL.emax.R
PopED/tests/testthat/examples_fcn_doc/examples_tic.R
PopED/tests/testthat/examples_fcn_doc/warfarin_optimize.R
PopED/tests/testthat/examples_fcn_doc/examples_mftot5.R
PopED/tests/testthat/examples_fcn_doc/examples_mf.R
PopED/tests/testthat/examples_fcn_doc/examples_blockexp.R
PopED/tests/testthat/examples_fcn_doc/examples_mf3.R
PopED/tests/testthat/examples_fcn_doc/examples_calc_ofv_and_grad.R
PopED/tests/testthat/examples_fcn_doc/examples_create_design_space.R
PopED/tests/testthat/examples_fcn_doc/examples_evaluate.fim.R
PopED/tests/testthat/examples_fcn_doc/examples_LinMatrixLH.R
PopED/tests/testthat/examples_fcn_doc/examples_randn.R
PopED/tests/testthat/examples_fcn_doc/examples_blockheader.R
PopED/tests/testthat/examples_fcn_doc/examples_mf8.R
PopED/tests/testthat/examples_fcn_doc/examples_plot_efficiency_of_windows.R
PopED/tests/testthat/examples_fcn_doc/examples_ofv_criterion.R
PopED/tests/testthat/examples_fcn_doc/examples_poped_optim.R
PopED/tests/testthat/examples_fcn_doc/examples_poped_optimize.R
PopED/tests/testthat/examples_fcn_doc/examples_size.R
PopED/tests/testthat/examples_fcn_doc/examples_downsizing_general_design.R
PopED/tests/testthat/examples_fcn_doc/examples_test_for_max.R
PopED/tests/testthat/examples_fcn_doc/examples_evaluate.e.ofv.fim.R
PopED/tests/testthat/examples_fcn_doc/examples_LinMatrixL_occ.R
PopED/tests/testthat/examples_fcn_doc/examples_ofv_fim.R
PopED/tests/testthat/examples_fcn_doc/warfarin_basic.R
PopED/tests/testthat/examples_fcn_doc/examples_create_design.R
PopED/tests/testthat/examples_fcn_doc/examples_evaluate_design.R
PopED/tests/testthat/examples_fcn_doc/examples_test_for_min.R
PopED/tests/testthat/examples_fcn_doc/examples_cell.R
PopED/tests/testthat/examples_fcn_doc/examples_log_prior_pdf.R
PopED/tests/testthat/examples_fcn_doc/examples_plot_model_prediction.R
PopED/tests/testthat/examples_fcn_doc/examples_get_all_params.R
PopED/tests/testthat/PopED_output_summary_RS.txt
PopED/tests/testthat/test_evaluate.fim.R
PopED/tests/testthat/test_optimization.R
PopED/tests/testthat/helper_options.R
PopED/tests/testthat/test_E_family.R
PopED/tests/testthat/PopED_output_summary_RS_1.txt
PopED/tests/testthat/helper_functions.R
PopED/tests/testthat/test_create_databases.R
PopED/tests/testthat/test_examples.R
PopED/tests/testthat/test_distributions.R
PopED/tests/testthat/test_evaluate_design.R
PopED/tests/testthat/test_predictions.R
PopED/NAMESPACE
PopED/NEWS
PopED/R
PopED/R/mf3.R
PopED/R/mftot1.R
PopED/R/zeros.R
PopED/R/m4.R
PopED/R/mftot5.R
PopED/R/summary.poped_optim.R
PopED/R/mfea.R
PopED/R/mftot7.R
PopED/R/models.R
PopED/R/blockopt.R
PopED/R/getfulld.R
PopED/R/v.R
PopED/R/write_matrix.R
PopED/R/write_iterationfile.R
PopED/R/line_search_uc.R
PopED/R/ed_mftot.R
PopED/R/datestr_poped.R
PopED/R/mf7.R
PopED/R/gradofv_xt.R
PopED/R/trace_matrix.R
PopED/R/ones.R
PopED/R/mf_all.R
PopED/R/test_for_max.R
PopED/R/dfimdalpha.R
PopED/R/fileparts.R
PopED/R/projected_gradient_norm.R
PopED/R/size.R
PopED/R/mftot2.R
PopED/R/feval.R
PopED/R/ofv_criterion.R
PopED/R/LEDoptim.R
PopED/R/graddetmfxt.R
PopED/R/bfgsb_min.R
PopED/R/update_offdiag.R
PopED/R/graddetmfxt_ext.R
PopED/R/gradff.R
PopED/R/gradfg.R
PopED/R/kron_tmp.R
PopED/R/a_line_search.R
PopED/R/evaluate.e.ofv.fim.R
PopED/R/mc_mean.R
PopED/R/isnan.R
PopED/R/mf5.R
PopED/R/d2fimdalpha2.R
PopED/R/matrix_any.R
PopED/R/update_designinlist.R
PopED/R/get_unfixed_params.R
PopED/R/fullfile.R
PopED/R/get_all_params.R
PopED/R/start_parallel.R
PopED/R/create_design.R
PopED/R/hessian_eta_complex.R
PopED/R/calc_ofv_and_fim.R
PopED/R/RS_opt.R
PopED/R/inv.R
PopED/R/isempty.R
PopED/R/evaluate_design.R
PopED/R/get_cov_matrix_index.R
PopED/R/poped_optimize.R
PopED/R/line_search.R
PopED/R/subspace_min.R
PopED/R/test_mat_size.R
PopED/R/mftot.R
PopED/R/create.poped.database.R
PopED/R/RS_opt_gen.R
PopED/R/LinMatrixLH.R
PopED/R/Dtrace.R
PopED/R/ind_likelihood.R
PopED/R/LinMatrixL.R
PopED/R/mf8.R
PopED/R/grouped_rand.R
PopED/R/m3.R
PopED/R/blockoptwrt.R
PopED/R/graddetmfa_ext.R
PopED/R/gradlndetmfxt_ext.R
PopED/R/tic.R
PopED/R/test_for_zeros.R
PopED/R/convert_variables.R
PopED/R/gradofv_a.R
PopED/R/mftot4.R
PopED/R/graddetmfa.R
PopED/R/find_matlab.R
PopED/R/poped_optim.R
PopED/R/cell.R
PopED/R/m2.R
PopED/R/mftot0.R
PopED/R/isinf.R
PopED/R/ed_laplace_ofv.R
PopED/R/model_prediction.R
PopED/R/create_design_space.R
PopED/R/isfield.R
PopED/R/randn.R
PopED/R/LinMatrixL_occ.R
PopED/R/poped_gui.R
PopED/R/matrix_all.R
PopED/R/get_discrete_x.R
PopED/R/fprintf.R
PopED/R/toc.R
PopED/R/pargen.R
PopED/R/test_for_min.R
PopED/R/Doptim.R
PopED/R/linspace.R
PopED/R/mftot6.R
PopED/R/rem.R
PopED/R/writet.R
PopED/R/limit_value.R
PopED/R/optim_LS.R
PopED/R/median_hilow_poped.R
PopED/R/rand.R
PopED/R/PopED.R
PopED/R/blockfinal.R
PopED/R/get_vector_str.R
PopED/R/gradfg_occ.R
PopED/R/cauchy_point.R
PopED/R/blockheader.R
PopED/R/ofv_fim.R
PopED/R/mf6.R
PopED/R/get_fim_size.R
PopED/R/numel.R
PopED/R/getTruncatedNormal.R
PopED/R/build_sfg.R
PopED/R/plot_efficiency_of_windows.R
PopED/R/mftot3.R
PopED/R/blockexp.R
PopED/R/grouped_rand_a.R
PopED/R/log_prior_pdf.R
PopED/R/evaluate.fim.R
PopED/R/blockother.R
PopED/R/randperm.R
PopED/R/reshape_matlab.R
PopED/R/gradtrmfxt.R
PopED/R/hesskalpha2.R
PopED/R/gradtrmfa.R
PopED/R/mf.R
PopED/R/gradlndetmfa_ext.R
PopED/R/plot_model_prediction.R
PopED/R/get_cv.R
PopED/R/zzz.R
PopED/R/downsizing_general_design.R
PopED/R/diag_matlab.R
PopED/R/find.largest.index.R
PopED/R/LinMatrixH.R
PopED/R/gradlndetmfxt.R
PopED/R/optim_ARS.R
PopED/R/m1.R
PopED/R/gradlndetmfa.R
PopED/R/ind_estimates.R
PopED/vignettes
PopED/vignettes/intro-poped_cache
PopED/vignettes/intro-poped_cache/html
PopED/vignettes/intro-poped_cache/html/cost_optimization_f0f2d6281f61cf558abf1fc1f5bdf3c8.rdx
PopED/vignettes/intro-poped_cache/html/optimize_a2c5cd3f5dcf8a020a7e81c8d4ea906a.RData
PopED/vignettes/intro-poped_cache/html/__packages
PopED/vignettes/intro-poped_cache/html/optimize_a2c5cd3f5dcf8a020a7e81c8d4ea906a.rdx
PopED/vignettes/intro-poped_cache/html/optimize_dose_cc36fad2848e2f8b1aad976956b56449.rdx
PopED/vignettes/intro-poped_cache/html/cost_optimization_f0f2d6281f61cf558abf1fc1f5bdf3c8.RData
PopED/vignettes/intro-poped_cache/html/optimize_dose_cc36fad2848e2f8b1aad976956b56449.rdb
PopED/vignettes/intro-poped_cache/html/optimize_a2c5cd3f5dcf8a020a7e81c8d4ea906a.rdb
PopED/vignettes/intro-poped_cache/html/unnamed-chunk-10_e364407314b7746b9082627be42c8a28.rdb
PopED/vignettes/intro-poped_cache/html/optimize_dose_cc36fad2848e2f8b1aad976956b56449.RData
PopED/vignettes/intro-poped_cache/html/unnamed-chunk-10_e364407314b7746b9082627be42c8a28.RData
PopED/vignettes/intro-poped_cache/html/cost_optimization_f0f2d6281f61cf558abf1fc1f5bdf3c8.rdb
PopED/vignettes/intro-poped_cache/html/unnamed-chunk-10_e364407314b7746b9082627be42c8a28.rdx
PopED/vignettes/intro-poped.Rmd
PopED/vignettes/intro-poped_files
PopED/vignettes/intro-poped_files/figure-html
PopED/vignettes/intro-poped_files/figure-html/simulate_with_BSV-1.png
PopED/vignettes/intro-poped_files/figure-html/unnamed-chunk-14-1.png
PopED/vignettes/intro-poped_files/figure-html/unnamed-chunk-12-1.png
PopED/vignettes/intro-poped_files/figure-html/unnamed-chunk-9-1.png
PopED/vignettes/intro-poped_files/figure-html/unnamed-chunk-10-1.png
PopED/vignettes/intro-poped_files/figure-html/unnamed-chunk-6-1.png
PopED/README.md
PopED/MD5
PopED/build
PopED/build/vignette.rds
PopED/DESCRIPTION
PopED/man
PopED/man/Dtrace.Rd
PopED/man/isempty.Rd
PopED/man/calc_ofv_and_fim.Rd
PopED/man/create_design.Rd
PopED/man/mftot3.Rd
PopED/man/mftot5.Rd
PopED/man/mf8.Rd
PopED/man/downsizing_general_design.Rd
PopED/man/mftot2.Rd
PopED/man/calc_autofocus.Rd
PopED/man/create_design_space.Rd
PopED/man/calc_ofv_and_grad.Rd
PopED/man/LinMatrixH.Rd
PopED/man/ff.PK.1.comp.oral.md.KE.Rd
PopED/man/LinMatrixLH.Rd
PopED/man/test_for_max.Rd
PopED/man/toc.Rd
PopED/man/poped_gui.Rd
PopED/man/mftot.Rd
PopED/man/mftot1.Rd
PopED/man/ff.PKPD.1.comp.sd.CL.emax.Rd
PopED/man/convert_variables.Rd
PopED/man/ones.Rd
PopED/man/mf.Rd
PopED/man/test_for_zeros.Rd
PopED/man/plot_model_prediction.Rd
PopED/man/fileparts.Rd
PopED/man/zeros.Rd
PopED/man/optim_LS.Rd
PopED/man/rand.Rd
PopED/man/mftot0.Rd
PopED/man/feps.add.prop.Rd
PopED/man/blockheader.Rd
PopED/man/LinMatrixL.Rd
PopED/man/getfulld.Rd
PopED/man/mf3.Rd
PopED/man/ff.PK.1.comp.oral.sd.KE.Rd
PopED/man/blockexp.Rd
PopED/man/Doptim.Rd
PopED/man/poped_optimize.Rd
PopED/man/median_hilow_poped.Rd
PopED/man/model_prediction.Rd
PopED/man/LEDoptim.Rd
PopED/man/pargen.Rd
PopED/man/LinMatrixL_occ.Rd
PopED/man/test_for_min.Rd
PopED/man/tic.Rd
PopED/man/create.poped.database.Rd
PopED/man/ff.PK.1.comp.oral.md.CL.Rd
PopED/man/a_line_search.Rd
PopED/man/getTruncatedNormal.Rd
PopED/man/mfea.Rd
PopED/man/ed_laplace_ofv.Rd
PopED/man/test_mat_size.Rd
PopED/man/mftot7.Rd
PopED/man/evaluate_design.Rd
PopED/man/blockopt.Rd
PopED/man/randn.Rd
PopED/man/evaluate.e.ofv.fim.Rd
PopED/man/feps.add.Rd
PopED/man/get_all_params.Rd
PopED/man/plot_efficiency_of_windows.Rd
PopED/man/mftot6.Rd
PopED/man/ff.PKPD.1.comp.oral.md.CL.imax.Rd
PopED/man/size.Rd
PopED/man/feval.Rd
PopED/man/mf6.Rd
PopED/man/isfield.Rd
PopED/man/mc_mean.Rd
PopED/man/RS_opt.Rd
PopED/man/ff.PK.1.comp.oral.sd.CL.Rd
PopED/man/mftot4.Rd
PopED/man/gradf_eps.Rd
PopED/man/optim_ARS.Rd
PopED/man/cell.Rd
PopED/man/poped.choose.Rd
PopED/man/inv.Rd
PopED/man/efficiency.Rd
PopED/man/ofv_criterion.Rd
PopED/man/start_parallel.Rd
PopED/man/get_rse.Rd
PopED/man/mf5.Rd
PopED/man/evaluate.fim.Rd
PopED/man/poped_optim.Rd
PopED/man/log_prior_pdf.Rd
PopED/man/ed_mftot.Rd
PopED/man/bfgsb_min.Rd
PopED/man/RS_opt_gen.Rd
PopED/man/get_unfixed_params.Rd
PopED/man/blockfinal.Rd
PopED/man/feps.prop.Rd
PopED/man/PopED.Rd
PopED/man/randperm.Rd
PopED/man/diag_matlab.Rd
PopED/man/mf7.Rd
PopED/man/ofv_fim.Rd