# Power2Stage: Power and Sample-Size Distribution of 2-Stage Bioequivalence Studies

Functions to obtain the operational characteristics of bioequivalence studies with 2-stage designs via simulations - Contains a function to calculate power and sample-size distribution of 2-stage bioequivalence (BE) studies with a 2x2 crossover design according to Potvin et al. / Montague et al. modified to include a futility Nmax and modified to do the sample size estimation step with PE and mse of stage 1. - Contains further a function with the modifications according to Karalis & Macheras which use both point estimate (PE) and mse from stage 1 also for the power monitoring steps. - The third function power.2stage.fC() calculates power and sample-size distribution of 2-stage BE studies with a futility criterion for the PE or CI of T/R from stage 1. - The fourth function power.2stage.GS() calculates power of non-adaptive group sequential (2-stage) BE studies. - The fifth function power.2stage.p() calculates power and sample size distribution of 2-stage BE studies with 2 parallel groups. This function has a sibling power.2stage.pAF(), which performs exactly as described in A.Fuglsang 2014 - Another function power.2stage.ssr() allows the power calculation for 2-stage studies with (blinded) interim sample size re-estimation.

- Author
- Detlew Labes [aut, cre], Helmut Schuetz [ctb]
- Date of publication
- 2015-11-26 08:42:22
- Maintainer
- Detlew Labes <DetlewLabes@gmx.de>
- License
- GPL (>= 2)
- Version
- 0.4-3

## Man pages

- power.2stage
- Power calculation of adaptive 2-stage BE studies with 2x2...
- power.2stage
- Power calculation of adaptive 2-stage BE studies with 2x2...
- power.2stage.fC
- Power calculation of adaptive 2-stage BE studies (2x2...
- power.2stage.fC
- Power calculation of adaptive 2-stage BE studies (2x2...
- power.2stage.GS
- Power calculation for non-adaptive group sequential (2-stage)...
- power.2stage.GS
- Power calculation for non-adaptive group sequential (2-stage)...
- power.2stage.KM
- Power calculation of adaptive 2-stage BE studies (2x2...
- power.2stage.KM
- Power calculation of adaptive 2-stage BE studies (2x2...
- power.2stage.p
- Power calculation of adaptive 2-stage BE studies with 2-group...
- power.2stage.p
- Power calculation of adaptive 2-stage BE studies with 2-group...
- power.2stage.ssr
- Power of 2-stage BE studies with 2x2 crossover design with...
- power.2stage.ssr
- Power of 2-stage BE studies with 2x2 crossover design with...

## Files in this package

Power2Stage |

Power2Stage/NAMESPACE |

Power2Stage/NEWS |

Power2Stage/R |

Power2Stage/R/power_2stage_parallel.R |

Power2Stage/R/power_2stage_fC.R |

Power2Stage/R/print_pwrtsd_s3.R |

Power2Stage/R/power.R |

Power2Stage/R/power_2stage_SSR.R |

Power2Stage/R/power_2stage_parallel_AF.R |

Power2Stage/R/power_2stage.R |

Power2Stage/R/power_2stage_KM.R |

Power2Stage/R/power_2stage_GS.R |

Power2Stage/R/sampsiz_n0.R |

Power2Stage/R/sampsiz2.R |

Power2Stage/R/power_2stage_DL.R |

Power2Stage/MD5 |

Power2Stage/DESCRIPTION |

Power2Stage/man |

Power2Stage/man/power.2stage.GS.Rd |

Power2Stage/man/power.2stage.ssr.Rd |

Power2Stage/man/power.2stage.Rd |

Power2Stage/man/power.2stage.fC.Rd |

Power2Stage/man/power.2stage.p.Rd |

Power2Stage/man/power.2stage.KM.Rd |