Power2Stage: Power and Sample-Size Distribution of 2-Stage Bioequivalence Studies

Functions to obtain the operational characteristics of bioequivalence studies with 2-stage designs via simulations - Contains a function to calculate power and sample-size distribution of 2-stage bioequivalence (BE) studies with a 2x2 crossover design according to Potvin et al. / Montague et al. modified to include a futility Nmax and modified to do the sample size estimation step with PE and mse of stage 1. - Contains further a function with the modifications according to Karalis & Macheras which use both point estimate (PE) and mse from stage 1 also for the power monitoring steps. - The third function power.2stage.fC() calculates power and sample-size distribution of 2-stage BE studies with a futility criterion for the PE or CI of T/R from stage 1. - The fourth function power.2stage.GS() calculates power of non-adaptive group sequential (2-stage) BE studies. - The fifth function power.2stage.p() calculates power and sample size distribution of 2-stage BE studies with 2 parallel groups. This function has a sibling power.2stage.pAF(), which performs exactly as described in A.Fuglsang 2014 - Another function power.2stage.ssr() allows the power calculation for 2-stage studies with (blinded) interim sample size re-estimation.

Author
Detlew Labes [aut, cre], Helmut Schuetz [ctb]
Date of publication
2015-11-26 08:42:22
Maintainer
Detlew Labes <DetlewLabes@gmx.de>
License
GPL (>= 2)
Version
0.4-3

View on CRAN

Man pages

power.2stage
Power calculation of adaptive 2-stage BE studies with 2x2...
power.2stage.fC
Power calculation of adaptive 2-stage BE studies (2x2...
power.2stage.GS
Power calculation for non-adaptive group sequential (2-stage)...
power.2stage.KM
Power calculation of adaptive 2-stage BE studies (2x2...
power.2stage.p
Power calculation of adaptive 2-stage BE studies with 2-group...
power.2stage.ssr
Power of 2-stage BE studies with 2x2 crossover design with...

Files in this package

Power2Stage
Power2Stage/NAMESPACE
Power2Stage/NEWS
Power2Stage/R
Power2Stage/R/power_2stage_parallel.R
Power2Stage/R/power_2stage_fC.R
Power2Stage/R/print_pwrtsd_s3.R
Power2Stage/R/power.R
Power2Stage/R/power_2stage_SSR.R
Power2Stage/R/power_2stage_parallel_AF.R
Power2Stage/R/power_2stage.R
Power2Stage/R/power_2stage_KM.R
Power2Stage/R/power_2stage_GS.R
Power2Stage/R/sampsiz_n0.R
Power2Stage/R/sampsiz2.R
Power2Stage/R/power_2stage_DL.R
Power2Stage/MD5
Power2Stage/DESCRIPTION
Power2Stage/man
Power2Stage/man/power.2stage.GS.Rd
Power2Stage/man/power.2stage.ssr.Rd
Power2Stage/man/power.2stage.Rd
Power2Stage/man/power.2stage.fC.Rd
Power2Stage/man/power.2stage.p.Rd
Power2Stage/man/power.2stage.KM.Rd