Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.
Package details |
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Author | Junwei Han [ctb, cre], Jieyi Di [aut], Baotong Zheng [aut] |
Maintainer | Junwei Han <hanjunwei1981@163.com> |
License | GPL (>= 2) |
Version | 0.1.0 |
Package repository | View on CRAN |
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