Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drugdrug functional similarity network. 1) We firstly constructed a drugdrug functional similarity network by integrating pathway activity and drug activity derived from the NCI60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drugdrug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.
Package details 


Author  Junwei Han [ctb, cre], Jieyi Di [aut], Baotong Zheng [aut] 
Maintainer  Junwei Han <[email protected]> 
License  GPL (>= 2) 
Version  0.1.0 
Package repository  View on CRAN 
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