PriorCD: Prioritizing Cancer Drugs for Interested Cancer

Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.

Package details

AuthorJunwei Han [ctb, cre], Jieyi Di [aut], Baotong Zheng [aut]
MaintainerJunwei Han <[email protected]>
LicenseGPL (>= 2)
Version0.1.0
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("PriorCD")

Try the PriorCD package in your browser

Any scripts or data that you put into this service are public.

PriorCD documentation built on Feb. 24, 2019, 5:05 p.m.