envData: The variables in the environment include an example profile,...

Description Format Details Author(s)

Description

Drug repurposing has become the focus of experts in drug development. In PriorCD, pathway activities and drug activities are combine to construct drug functional similarity network, and on which a global network propagation algorithm is applied. First, drug functional similarity network is constructed by the correlation and fdr of drug pairs. Then a global netwokr propagation (RWR) is performed on this network to prioritize candidates. Finally, ROC and network structure of the result can be browsed in PriorCD by getROC and getDDN functions.

Format

An environment variable

Details

The environment variable includes the variable drug.edgelist, drug.info,brc_candidates,breast_cancer,drug.fdr,drug.r,drug.ic50,mRNA_path,microRNA_path,priorlist

Author(s)

Junwei Hanhanjunwei1981@163.com,Baotong Zhengbtzheng1116@163.com,Jieyi Didijy_0419@yeah.net


PriorCD documentation built on May 2, 2019, 7:28 a.m.