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A Quantile Rank-score (QRank) based test for the identification of expression quantitative trait loci (eQTLs).
We use a Quantile Rank-score (QRank) based test to identify the expression quantitative trait loci (eQTLs) that are associated with the conditional quantile function of gene expressions.
Xiaoyu Song
Maintainer: Xiaoyu Song <xs2148@cumc.columbia.edu>
Xiaoyu Song, Gen Li, Zhenwei Zhou, Xianling Wang, Iuliana Ionita-Laza and Ying Wei (2016). QRank: A Novel Quantile Regression Tool for eQTL Discovery. Under revision for Bioinformatics.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 | set.seed(123) #
n=300 #
x=rbinom(n, 2, 0.2) #
y=rnorm(n, mean=0, sd=1) #
z=cbind(rbinom(n, 1, 0.3), rnorm(n, mean=2, sd=2)) #
taus=c( 0.25, 0.5, 0.75) #
# - run the proposed QRank approach #
QRank(gene=y, snp=x, cov=z, tau=taus) #
# - output #
#Composite.pvalue: #
#[1] 0.2241873 #
#Quantile.specific.pvalue: #
# 0.25 0.5 0.75 #
#0.5452044 0.1821452 0.5938421 #
|
Composite.pvalue:
[1] 0.2241873
Quantile.specific.pvalue:
0.25 0.5 0.75
0.5452044 0.1821452 0.5938421
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