Description Usage Arguments Details Value Author(s) References See Also Examples

Computes, for each pair of final descendants in the pedigree structure contained in the `pedigree`

object, the ratio of the difference between the inferred and expected kinship coefficient for the pair over the mean kinship among founders.

1 2 | ```
## S4 method for signature 'RVsharingProb'
ComputeKinshipPropCoef(obj)
``` |

`obj` |
obj is a |

The ratio for each pair of final descendants is computed using equation (A1) of Bureau et al. Dividing the difference between the inferred and expected kinship coefficient for each pair by this ratio gives a pair-specific estimate of the mean kinship among founders, which can then be averaged over all pairs of final descendants from the same population to obtain a global estimate of the mean kinship among founders.

A symmetric matrix of ratios for all pair of final descendants in the pedigree structure contained in the `pedigree`

object.

Alexandre Bureau <[email protected]>

Bureau, A., Younkin, S., Parker, M.M., Bailey-Wilson, J.E., Marazita, M.L., Murray, J.C., Mangold, E., Albacha-Hejazi, H., Beaty, T.H. and Ruczinski, I. (2014) Inferring rare disease risk variants based on exact probabilities of sharing by multiple affected relatives. Bioinformatics, 30(15): 2189-96, doi:10.1093/bioinformatics/btu198.

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RVsharing documentation built on May 29, 2017, 6:14 p.m.

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