RefFreeEWAS: EWAS using Reference-Free DNA Methylation Mixture Deconvolution

Reference-free method for conducting EWAS while deconvoluting DNA methylation arising as mixtures of cell types. The older method (Houseman et al., 2014,<doi:10.1093/bioinformatics/btu029>) is similar to surrogate variable analysis (SVA and ISVA), except that it makes additional use of a biological mixture assumption. The newer method (Houseman et al., 2016, <doi:10.1186/s12859-016-1140-4>) is similar to non-negative matrix factorization, with additional constraints and additional utilities.

Getting started

Package details

AuthorE. Andres Houseman, Sc.D.
MaintainerE. Andres Houseman <[email protected]>
LicenseGPL (>= 2)
Package repositoryView on CRAN
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RefFreeEWAS documentation built on Dec. 14, 2018, 9:04 a.m.