RefFreeEWAS: EWAS using Reference-Free DNA Methylation Mixture Deconvolution

Reference-free method for conducting EWAS while deconvoluting DNA methylation arising as mixtures of cell types. The older method (Houseman et al., 2014,<doi:10.1093/bioinformatics/btu029>) is similar to surrogate variable analysis (SVA and ISVA), except that it makes additional use of a biological mixture assumption. The newer method (Houseman et al., 2016, <doi:10.1186/s12859-016-1140-4>) is similar to non-negative matrix factorization, with additional constraints and additional utilities.

Getting started

Package details

AuthorE. Andres Houseman, Sc.D.
MaintainerE. Andres Houseman <>
LicenseGPL (>= 2)
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:

Try the RefFreeEWAS package in your browser

Any scripts or data that you put into this service are public.

RefFreeEWAS documentation built on May 2, 2019, 5:52 a.m.