Description Usage Arguments Value
Simulates replicates from a Sub-TITE trial with user specified true toxicity time distributions for different doses and subgroups and returns average summary statistics of the trial.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 | SimTrial1(
nSims,
Nmax,
T1,
Target,
Dose,
DoseStart,
Upper,
Accrue,
groupprob,
Family,
Param1,
Param2,
meanmu,
meanslope,
MeanInts,
MeanSlopes,
varint,
varbeta,
phetero,
NSep,
NBorrow,
cohort,
FULLY
)
|
nSims |
Number of Trials to Simulate. |
Nmax |
Maximum Number of Patients to enroll in the trial. |
T1 |
Reference time for toxicity. |
Target |
Target cumulative toxicity probability (or subgroup specific vector) at time T1. |
Dose |
Standardized vector of doses to try. |
DoseStart |
Dose (or vector of Doses) to enroll the first patient in each subgroup at. |
Upper |
Cutoff values used to determine if accrual in a subgroup should be suspended. |
Accrue |
Expected montly patient accrual rate. |
groupprob |
Probability vector of subgroup assignment. |
Family |
What distribution Family to simulate from. Options include: Exponential,Gamma, Lognormal, Uniform, Weibull. |
Param1 |
nGroups X nDose matrix of first parameter values. |
Param2 |
NGroups X nDose matrix of second parameter values. |
meanmu |
Prior mean of the baseline intercept parameter. |
meanslope |
Prior mean of the baseline slope parameter. |
MeanInts |
G-1 length vector of subgroup specific prior intercept means. |
MeanSlopes |
G-1 length vector of subgroup specific prior slope means. |
varint |
Prior Variance of Intercept Parameters. |
varbeta |
Prior Variance of Slope Parameters. |
phetero |
Prior prob of heterogeneity. |
NSep |
Number of patients to assign based on no borrowing. |
NBorrow |
Number of patients to assign based on no clustering |
cohort |
Number of patients to enroll before escalating. |
FULLY |
Do we have to fully evaluate a cohort before escalating? |
A list of simulation outputs to be processed in R.
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