GetPriorMeans: Calibrates prior means for Dose Finding Trial

Description Usage Arguments Value References Examples

View source: R/GetPriorMeans.R

Description

Uses the clinician elicited prior reference probabilities for each subgroup and dose to obtain prior means for the Bayesian logistic regression model used in the SubTite trial design.

Usage

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GetPriorMeans(Prior, Dose)

Arguments

Prior

#Groups X #Doses matrix containing the elicited prior toxicity probabilities at the reference time for each dose and subgroup.

Dose

Vector containing standardized doses.

Value

Returns the a list containing the nonlinear regression model whos parameter estimates will be used as prior means for the SubTITE Design.

References

[1] Chapple and Thall (2017), Subgroup-specific dose finding in phase I clinical trials based on time to toxicity allowing adaptive subgroup combination

Examples

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##Specify elicited reference toxicity probabilities
Prior = matrix(c(.2,.3,.4,.5,.6,.1,.2,.3,.4,.5,.05,.1,.15,.2,.3),byrow=TRUE,nrow=3)
Dose=sort(rnorm(5))
GetPriorMeans(Prior,Dose)

SubTite documentation built on Sept. 15, 2021, 9:07 a.m.