MCMC: Performs MCMC and returns needed values for dose-finding in a...

In SubTite: Subgroup Specific Optimal Dose Assignment

Description

Performs MCMC and returns needed values for dose-finding in a list.

Usage

MCMC(
  Y,
  I,
  Doses,
  Groups,
  T1,
  Target,
  Upper,
  Dose,
  meanmu,
  meanslope,
  MeanInts,
  MeanSlopes,
  varint,
  varbeta,
  phetero,
  Stopped,
  NumPat,
  SubRout,
  B
)

Arguments

Y	Vector containing observed event or censoring times.
I	Vector containing event indicators (1 if patient experiences an event for a patient).
Doses	Vector containing Doses of patients in trial.
Groups	Vector containing group assignment of patients, 0 is baseline group.
T1	Reference time for toxicity.
Target	Target cumulative toxicity probability vector at time T1.
Upper	Cutoff values used to determine if accrual in a subgroup should be suspended.
Dose	Vector containing the standardized doses considered.
meanmu	Prior mean for baseline intercept.
meanslope	Prior mean for baseline slope.
MeanInts	Vector of prior means for the group specific intercept parameters.
MeanSlopes	Vector of prior means for the group specific slope parameters.
varint	Prior variance for the intercept parameters.
varbeta	Prior variance for the slope parameters.
phetero	Prior probability of heterogeneous subgroups.
Stopped	Current vector of STOPPED groups
NumPat	Number of patients
SubRout	Parameter to specify subgroup borrowing/clustering. 0=No borrowing, 1=Borrowing but no clustering, 2=Borrowing and clustering.
B	Number of Iterations to run for MCMC

Value

A list of quantities needed for determining the next dose to enroll each subgroup.

SubTite documentation built on Sept. 15, 2021, 9:07 a.m.