cox.interaction: Interaction Cox AIM
In SubgrpID: Patient Subgroup Identification for Clinical Drug Development

Interaction Cox AIM

1 2	cox.interaction(x, trt, y, delta, nsteps = 8, mincut = 0.1, backfit = F, maxnumcut = 1, dirp = 0)

`x`	the predictor matrix.
`trt`	the treatment indicator vector.
`y`	the vector of the time to event response variable.
`delta`	status indicator: 1=failure 0=alive
`nsteps`	the maximum number of binary rules to be included in the index.
`mincut`	the minimum cutting proportion for the binary rule at either end. It typically is between 0 and 0.2. It is the parameter in the functions of AIM package.
`backfit`	a logical argument indicating whether the existing cutpoints are adjusted after including new binary rule.
`maxnumcut`	the maximum number of binary splits per predictor.
`dirp`	a vector for pre-specified direction of the binary split for each of the predictors. 0 represents "no pre-given direction"; 1 represents "(x>cut)"; -1 represents "(x<cut)". Alternatively, "dirp=0" represents that there is no pre-given direction for any of the predictor.

"cox.interaction" returns "maxsc", which is the observed partial likelihood score test statistics for the index*treatment interaction in the fitted model and "res", which is a list with components

SubgrpID documentation built on May 2, 2019, 8:02 a.m.