Description Usage Arguments Details Value Author(s) References See Also Examples
This function implements the TKF91 model to estimate the pairwise distance from protein sequences.
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fasta 
A named list of sequences in vector of characters format.

mu 
A numeric value or NULL.
It is the death rate per normal link in TKF91 model.
When it is NULL, a joint estimation of 
distance 
A numeric value: the PAM distance between two protein sequences. When it is given, TKF91Pair only calculates the negative loglikelihood. 
expectedLength 
A numeric object: the expected length of input protein sequences. By default, the average sequence length, 362, from OMA browser is used. 
substModel 
A numeric matrix: the mutation probability from one AA to another AA at PAM distance 1. The order of AA in the matrix should be identical to AACharacterSet. 
substModelBF 
A vector of numeric: the backrgound frequency of AAs. The order of AA in the vector should also be identical to AACharacterSet. 
seq1, seq2 
A vector of character: the sequences of two proteins to compare. 
Currently this implementation only supports the normal 20 AAs. Missing or Ambiguous characters are not supported.
A list of matrices are returned: the matrix of estimated distances, the matrix of estimated distance variances, the matrix of negative loglikelihood between the sequences.
Ge Tan
Thorne, J.L., Kishino, H., and Felsenstein, J. (1991). An evolutionary model for maximum likelihood alignment of DNA sequences. J. Mol. Evol. 33, 114124.
Gonnet, G.H., Cohen, M.A., and Benner, S.A. (1992). Exhaustive matching of the entire protein sequence database. Science 256, 14431445.
AACharacterSet
,
GONNET
, GONNETBF
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## This example is not tested due to running time > 5s
data(GONNET)
data(GONNETBF)
library(seqinr)
fasta < read.fasta(file.path(system.file("extdata", package="TKF"),
"pair1.fasta"),
seqtype="AA", set.attributes=FALSE)
## 1D estimation: only distance
TKF91(fasta, mu=5.920655e04,
substModel=GONNET, substModelBF=GONNETBF)
## 2D estimation: joint estimation of distance and mu
TKF91(fasta, substModel=GONNET, substModelBF=GONNETBF)
## only apply to a pair of sequences
seq1 < fasta[[1]]
seq2 < fasta[[2]]
TKF91Pair(seq1, seq2, mu=5.920655e04,
substModel=GONNET, substModelBF=GONNETBF)

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