create_addl: Create ADDL data item and deletes unnecessary amount lines

In amp.dm: Data Management Tools for Pharmacometrics

Create ADDL data item and deletes unnecessary amount lines

Description

This function determines if subsequent dose items are exactly the same as the tau value. If this is the case it will count the number of times this occur and create the applicable number of additional dose levels and removes unnecessary rows

Usage

create_addl(data, datetime, id, dose, tau, evid = NULL)

Arguments

data	data frame to perform the action on
datetime	character identifying the date/time variable (POSIXct) within the data frame
id	character identifying the subject ID within the data frame
dose	character identifying the dose within the data frame (ADDL can only be set for equal doses)
tau	character identifying the tau (or II) within the data frame
evid	character identifying the event ID (EVID) within the data frame. This is used to distinguish observations from dosing records, e.g. 0 for observations

Value

a data frame with ADDL records added

Author(s)

Richard Hooijmaijers

Examples

dts  <- c(Sys.time(),Sys.time() + (24*60*60),Sys.time() + (48*60*60),Sys.time() + (96*60*60))
data <- data.frame(id=1,dt=dts,dose=10,tau=24)
create_addl(data=data, datetime="dt", id="id", dose="dose", tau="tau")

data2 <- rbind(cbind(data,evid=1),data.frame(id=1,dt=dts[4]+60,dose=10,tau=24,evid=0))
create_addl(data=data2, datetime="dt", id="id", dose="dose", tau="tau", evid="evid")

amp.dm documentation built on March 13, 2026, 5:08 p.m.