impute_dose: Imputes dose records using ADDL and II by looking forward and...

In amp.dm: Data Management Tools for Pharmacometrics

Imputes dose records using ADDL and II by looking forward and backwards

Description

This function imputes dose records by looking at the missing doses between available records based on a given II value

Usage

impute_dose(data, id, datetime, amt = "AMT", ii = "II", thr = 50, back = TRUE)

Arguments

data	data frame to perform the calculations on
id	character identifying the id variable within the data frame
datetime	character identifying the date/time variable (POSIXct) within the data frame
amt	character identifying the AMT (amount) variable within the data frame
ii	character identifying the II (Interdose Interval) variable within the data frame
thr	numeric indicating the threshold percentage for imputation (see details)
back	logical indicating if the time for imputed doses should be taken from the previous record (TRUE) or the next (FALSE)

Details

The function fills in the doses by looking at the time difference and II between all records. Be aware that this can result in unexpected results in a few cases, so results should always be handled with care. The function will determine if a dose should be imputed based on the 'thr' value. For each dose, the function determines the percentage difference from the previous dose based on the II value. In case this the expected difference is above the threshold value imputation will be done.

Value

a data frame with imputed dose records

Author(s)

Richard Hooijmaijers

Examples

dfrm <- data.frame(id=c(1,1), dt=c(Sys.time(),Sys.time()+ 864120),
                   II=c(24,24),AMT=c(10,10))
impute_dose(dfrm,"id","dt")

amp.dm documentation built on March 13, 2026, 5:08 p.m.