simsolvd: Simulated SOLVD-Trial data set

In anoint: Analysis of Interactions

Simulated SOLVD-Trial data set

Description

A simulated clinical trial based on the design of the Studies of Left Ventricular Dysfunction Trial (SOLVD-T), a placebo-controlled trial of the angiotensin-converting-enzyme inhibitor enalapril for patients with congestive heart failure.

Usage

data(simsolvd)

Format

A data frame with 2569 observations on the following 12 variables.

trt

indicator for enalapril group

age

age at baseline (centered and scaled)

beat

pulse at baseline (centered and scaled)

lymphocyte

lymphocyte count at baseline (centered and scaled)

lvef

left ventricular ejection fraction at baseline (centered and scaled)

noise

simulated vector of random uniform variables

nyha

indicator whether New York Heart Association score greater than 2

cardratio

indicator whether cardiothoracic ratio is greater than 0.5

creatinine

creatinine at baseline (centered and scaled)

sodium

sodium at baseline (centered and scaled)

ttodthorchfhosp

time to death or hospitalization in days

censor

indicator whether censored (1) or an event (0)

current

indicator whether current smoker

Source

Simulated data set based on the clinical study reported by: Yusuf, S. et al. (1991). Effect of Enalapril on Survival in Patients with Reduced Left-Ventricular Ejection Fractions and Congestive-Heart-Failure. NEJM 325:293-302.

Examples

data(simsolvd)

obj <- anoint(Surv(ttodthorchfhosp,censor==0)~(age+beat+lvef)*trt,
				data = simsolvd, family = "coxph")

uim(obj)$fit

anoint documentation built on Sept. 11, 2024, 8:49 p.m.