NEWS.md

In assemblerr: Assembly of Pharmacometric Models

assemblerr 0.1.1

• add CWRES to vars_nm_std
• pk_elimination_linear_nl gains support for CLmm and Vmax parameterization

assemblerr 0.1.0

• First release

assemblerr 0.0.0.9009

• automatically rename variables with conflicting capitalization (e.g., emax and EMAX)
• rename pk_elimination_linear_mm() to pk_elimination_linear_nl()
• remove pk_elimination_mm()
• extended help for PK component building blocks

assemblerr 0.0.0.9008

• extended help for the building blocks: parameter, observation, compartment, flow
• added pkgdown reference
• added new "Getting started" vignette

assemblerr 0.0.0.9007

• added task option to render function allowing to customize estimation and covariance records, e.g., render(m, tasks = tsk_estimation(method = "foce"))
• added tsk_ouput() to specify variables that should be added to $TABLE

assemblerr 0.0.0.9006

• RUV variance can be specified in the observation model obs_additive(~conc, var_add = 2)
• default parameter values for PK components
• parameter values can be defined when specifying parameters prm_normal("k", mean = 1, var = 1)
• variables that are not defined in the model are automatically added as input variables
• added warning when a new building block replaces an existing one

assemblerr 0.0.0.9005

• added pk_elimination_linear_mm for mixed linear-mm elimination
• models are now checked for issues before rendering
• improved console printing of building blocks and models

assemblerr 0.0.0.9004

• added check() function to check and list model issues
• improved error checking and reporting when creating building blocks, e.g., prm_normal()
• prediction declarations for observations do not longer need a left-hand side, e.g., obs_additive(~C["central"]) is now valid.
• pk_elimination_mm has been replaced with pk_elimination_nl to clarify that the default parameterization is not the classical MM model. Additionally, pk_elimination_nl allows selecting the classical parameterization using pk_elimination_nl(prm_vmax = prm_log_normal("vmax"), prm_clmm = NULL)
• unsupported building blocks are now ignored with a warning when added to a model (e.g., pk_model()+compartment('central'))
• option to include estimation & covariance step records in generated NONMEM model through render(m, options = assemblerr_options(default_record.covariance_step = nm_covariance()))
• Added a NEWS.md file to track changes to the package.

assemblerr documentation built on Jan. 13, 2022, 1:07 a.m.