Peto1980 | R Documentation |
Numbers of cases (patients) and events (deaths) in treatment and control groups of six studies.
data("Peto1980")
The data frame contains the following columns:
publication | character | publication reference |
study | character | study acronym or abbreviation |
start, end | integer | duration of study (calendar years) |
age | numeric | mean patient age (years) |
dose | numeric | total daily dose (mg) |
followup | numeric | follow-up duration (months) |
treat.cases | integer | number of cases in treatment group |
treat.events | integer | number of events in treatment group |
control.cases | integer | number of cases in control group |
control.events | integer | number of events in control group |
Peto (1980) investigated mortality data from six randomized, placebo-controlled clinical trials of aspirin, involving a total of 10,703 post-myocardial infarction patients. Canner (1987) later investigated potential heterogeneity between study characteristics as well as their reported estimates. The included studies' abbreviations are:
UK-1 | first United Kingdom trial |
CDPA | Coronary Drug Project Aspirin trial |
GAMS | German-Austrian Multicentre Study |
UK-2 | second United Kingdom trial |
PARIS | Persantine-Aspirin Reinfarction Study |
AMIS | Aspirin Myocardial Infarction Study |
P.L. Canner. An overview of six clinical trials of aspirin in coronary heart disease. Statistics in Medicine, 6(3):255-263, 1987. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1002/sim.4780060310")}
R. Peto. Aspirin after myocardial infarction. The Lancet, 315(8179):1172-1173, 1980. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1016/S0140-6736(80)91626-8")}.
P.C. Elwood, A.L. Cochrane, M.L.Burr, P.M. Sweetnam, G. Williams, E. Welsby, S.J. Hughes, R. Renton. A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction. British Medical Journal, 1(5905):436-440, 1974. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1136/bmj.1.5905.436")}.
The Coronary Drug Project Research Group. Aspirin in coronary heart disease. Journal of Chronic Diseases, 29(10):625-642, 1976. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1016/0021-9681(76)90020-5")}.
K. Breddin, D. Loew, K. Lechner, K. Ueberla, E. Walter. Secondary prevention of myocardial infarction: a comparison of acetylsalicylic acid, placebo and phenprocoumon. Haemostasis, 9(6):325-344, 1980. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1159/000214375")}.
P.C. Elwood, P.M. Sweetnam. Aspirin and secondary mortality after myocardial infarction. The Lancet, 314(8156):1313-1315, 1979. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1016/S0140-6736(79)92808-3")}.
Aspirin Myocardial Infarction Study Research Group. A randomized, controlled trial of aspirin in persons recovered from myocardial infarction. Journal of the American Medical Association, 243(7):661-669, 1980. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1001/jama.1980.03300330019023")}.
The Persantine-Aspirin Reinfarction Study Research Group. Persantine and aspirin in coronary heart disease. Circulation, 62(3):449-461, 1980. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1161/01.CIR.62.3.449")}.
data("Peto1980")
## Not run:
# compute effect sizes (log odds ratios) from count data
# (using "metafor" package's "escalc()" function):
require("metafor")
peto.es <- escalc(measure="OR",
ai=treat.events, n1i=treat.cases,
ci=control.events, n2i=control.cases,
slab=publication, data=Peto1980)
print(peto.es)
# check sensitivity to different prior choices:
peto.ma01 <- bayesmeta(peto.es)
peto.ma02 <- bayesmeta(peto.es, tau.prior=function(t){dhalfnormal(t, scale=1)})
par(mfrow=c(2,1))
plot(peto.ma01, which=4, prior=TRUE, taulim=c(0,1), main="uniform prior")
plot(peto.ma02, which=4, prior=TRUE, taulim=c(0,1), main="half-normal prior")
par(mfrow=c(1,1))
# compare heterogeneity (tau) estimates:
print(rbind("uniform" =peto.ma01$summary[,"tau"],
"half-normal"=peto.ma02$summary[,"tau"]))
# compare effect (mu) estimates:
print(rbind("uniform" =peto.ma01$summary[,"mu"],
"half-normal"=peto.ma02$summary[,"mu"]))
summary(peto.ma02)
forestplot(peto.ma02)
plot(peto.ma02)
## End(Not run)
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