traceplot.bayesmeta: Illustrate conditional means of study-specific estimates as...

In bayesmeta: Bayesian Random-Effects Meta-Analysis and Meta-Regression

Illustrate conditional means of study-specific estimates as well as overall mean (or other linear combinations) as a function of heterogeneity.

Description

Generates a trace plot of study-specific (shrinkage) estimates as a function of the heterogeneity (\tau), along with conditional estimates of the overall mean or other linear combinations of regression parameters. The heterogeneity's posterior distribution is also shown at the bottom.

Usage

  traceplot(x, ...)
  ## S3 method for class 'bayesmeta'
traceplot(x, mulim, taulim, ci=FALSE,
          ylab="effect", prior=FALSE, infinity=FALSE,
          rightmargin=8, col=rainbow(x$k), labcol=col,
          meanlabel="overall mean", meancol="black",
          meanlabcol=meancol, ...)
  ## S3 method for class 'bmr'
traceplot(x, mulim, taulim, ci=FALSE,
          ylab="effect", prior=FALSE, infinity=FALSE,
          rightmargin=8, col=rainbow(x$k), labcol=col,
          X, Xlabels, Xcols="black", Xlabcols=Xcols, ...)

Arguments

x	a bayesmeta or bmrobject.
mulim, taulim	(optional) ranges for the effect (mu) and heterogeneity (tau) axes. If only one value is given for taulim, then this is taken as the upper limit, and the lower limit is zero.
ci	a logical flag indicating whether to also show (conditional) confidence intervals.
ylab	a label for the effect (mu) axis.
prior	a logical flag indicating whether to show the (heterogeneity) prior density along with its posterior.
infinity	a logical flag indicating whether add an “infinity” tickmark to the heterogeneity (tau) axis and show the corresponding limiting values.
rightmargin	an additional margin to be added to the right side of the plot, in order to accomodate the estimates' labels. In case study labels still extend beyond the figure margin, try increasing this number.
col	colors to be used for plotting the (k) estimates.
labcol	colors to be used for labelling the (k) estimates.
meanlabel	a label for the overall mean estimate (traceplot.bayesmeta()).
meancol	colour specification for the overall mean estimate (traceplot.bayesmeta()).
meanlabcol	colour specification for the overall mean label (traceplot.bayesmeta()).
X	matrix (or vector) of coefficients defining linear combinations of regression parameters to be shown (traceplot.bmr()).
Xlabels	labels for the linear combinations (traceplot.bmr()).
Xcols	colour specification for the linear combinations (traceplot.bmr()).
Xlabcols	colour specification for the linear combination labels (traceplot.bmr()).
...	other arguments passed on to the plot() function.

Details

For a given heterogeneity (\tau) value, the conditional posterior distributions of the overall effect (\mu) as well as the study-specific parameters (\theta_i) are again normal. The conditional normal moments (mean and variance) then vary as functions of the heterogeneity; for large heterogeneity, the shrinkage estimates approach the original data (y_i), while the overall mean approaches an un-weighted overall average. For small heterogeneity, both overall mean as well as study-specific estimates are increasingly shrunk towards the inverse-variance-weighted ‘common-effect’ estimate (Roever, 2020).

This trace plot illustrates the conditional (overall and study-specific) estimates along with the heterogeneity's posterior distribution (density) in a layout similar to that utilized by Rubin (1981).

Author(s)

Christian Roever [e-mail]

References

C. Roever. Bayesian random-effects meta-analysis using the bayesmeta R package. Journal of Statistical Software, 93(6):1-51, 2020. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.18637/jss.v093.i06")}.

C. Roever, T. Friede. Using the bayesmeta R package for Bayesian random-effects meta-regression. Computer Methods and Programs in Biomedicine, 299:107303, 2023. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1016/j.cmpb.2022.107303")}.

D.B. Rubin. Estimation in parallel randomized experiments. Journal of Educational Statistics, 6(4):377-401, 1981. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.3102/10769986006004377")}.

DuMouchel, W. H. (1994). Hierarchical Bayes linear models for meta-analysis. Technical Report 27, National Institute of Statistical Sciences (NISS); Research Triangle Park, NC, USA. https://www.niss.org/research/technical-reports/hierarchical-bayes-linear-models-meta-analysis-1994

See Also

bayesmeta, bmr.

Examples

## Not run: 
########################
# SAT coaching example;
# load example data:
data("Rubin1981")

# perform meta-analysis:
bma01 <- bayesmeta(y=Rubin1981[,"effect"], sigma=Rubin1981[,"stderr"],
                  labels=Rubin1981[,"school"], tau.prior="uniform")

# show meta-analysis results:
forestplot(bma01)

# show trace plot:
traceplot(bma01)


##################################
# COPD (meta-regression) example;
# load example data,
# compute effect sizes (log-ORs):
data("KarnerEtAl2014")
karner.exa <- escalc(measure="OR",
                     ai=tiotropium.exa, n1i=tiotropium.total,
                     ci=placebo.exa,    n2i=placebo.total,
                     slab=study, data=KarnerEtAl2014)


#################################
# perform "plain" meta-analysis:
bma02 <- bayesmeta(karner.exa,
                   tau.prior=function(t){dhalfnormal(t, scale=0.5)})

traceplot(bma02, ylab="log-OR",
          prior=TRUE, infi=TRUE, taulim=0.53)

forestplot(bma02)


############################
# perform meta-regressions:

# 1st regression;
# specify regressor matrix
# (indicator variables, "short" vs. "long" study duration):
X1 <- cbind("short" = as.numeric(karner.exa$duration == "up to 1 year"),
            "long"  = as.numeric(karner.exa$duration == "1 year or longer"))

# perform meta-regression
# (two group means, common heterogeneity):
bmr01 <- bmr(karner.exa, X=X1,
             tau.prior=function(t){dhalfnormal(t, scale=0.5)})

# show trace plot:
traceplot(bmr01, ylab="log-OR", prior=TRUE,
          taulim=0.53, mulim=c(-1, 0.2),
          X=rbind("short" = c(1,0),
                  "long"  = c(0,1)))

# 2nd regression;
# specify regressor matrix
# (baseline FEV1, an indicator of disease severity):
X2 <- cbind("intercept" = 1,
            "fev1"      = karner.exa$baseline.fev1)

# perform meta-regression
# (linear effect of FEV1 on log-OR):
bmr02 <- bmr(karner.exa, X=X2,
             tau.prior=function(t){dhalfnormal(t, scale=0.5)})

traceplot(bmr02, ylab="log-OR", prior=TRUE,
          taulim=0.53, mulim=c(-1.0, 0.2),
          X=rbind("FEV1 = 1.0"=c(1,1.0),
                  "FEV1 = 1.5"=c(1,1.5),
                  "FEV1 = 2.0"=c(1,2.0)))

## End(Not run)

bayesmeta documentation built on July 9, 2023, 5:12 p.m.