Description Usage Arguments Details Value Author(s) See Also
Create a simulation model object for optimisation of the dose and sample size for a (or several, parallel) phase III clinical trial given phase II data. There is one efficacy response and one safety response obtained as sample means for each group of patients given a specific dose. These are both normal given the true populations means. The population means for efficacy and safety are in turn modeled using two independent Emax models.
1 2 | create.normal.model(theta.mu, theta.tau, eta.mu, eta.tau,
n.II, d.II, YE.II, YS.II, sigmaE, sigmaS, k.III, path.to.package = NA)
|
theta.mu |
A numeric, atomic vector with four elements that contains the mean parameters for the prior distributions for the efficacy model. |
theta.tau |
A numeric, atomic vector with four elements that contains the precision parameters for the prior distributions for the efficacy model. |
eta.mu |
A numeric, atomic vector with four elements that contains the mean parameters for the prior distributions for the safety model. |
eta.tau |
A numeric, atomic vector with four elements that contains the precision parameters for the prior distributions for the safety model. |
n.II |
A numeric, atomic vector of positive integers containing the group sample sizes corresponding to the phase II efficacy and safety responses. |
d.II |
A numeric, atomic vector containing the group dose levels corresponding to the phase II efficacy and safety responses. |
YE.II |
A numeric, atomic vector containing the observed sample means for the efficacy responses in the phase II trial. |
YS.II |
A numeric, atomic vector containing the observed sample means for the safety responses in the phase II trial. |
sigmaE |
The population standard deviation for an individual efficacy response. The population standard deviation for a group response is then obtained by dividing by the square root of the group sample size. |
sigmaS |
The population standard deviation for an individual safety response. The population standard deviation for a group response is then obtained by dividing by the square root of the group sample size. |
k.III |
A positive integer specifying the number of independent phase III trials, each of which consists of a single group. The sample size and dose is the same for all phase III trials. |
path.to.package |
The search path to the installation directory of bdpopt. For the
default value, the function will attempt to find the path using |
Note that n.II
, d.II
, YE.II
and YS.II
must
all be of the same length. Using the notation of the JAGS manual, the
prior distributions for theta
and eta
are given by
theta[i] ~ dnorm(theta.mu[i], theta.tau[i])
,
eta[i] ~ dnorm(eta.mu[i], eta.tau[i])
, for i = 1, 2
, and
theta[i] ~ dlnorm(theta.mu[i], theta.tau[i])
,
eta[i] ~ dlnorm(eta.mu[i], eta.tau[i])
, for i = 3, 4
.
A simulation model object of class sim.model
, created using the
data supplied as the arguments and the JAGS model file ‘normal_model_jags_model.R’.
Sebastian Jobj<f6>rnsson jobjorns@chalmers.se
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