Description Usage Arguments Details Value Author(s) References See Also Examples
Create objects representing bi- or trifactorial clinical trial designs.
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data |
A list of numeric or binary data vectors from the trial. See the details below for the order in which the list is to be given. |
D |
An integer vector of length 2 for |
... |
Any further arguments. |
The function carpet
creates objects of class carpet
from the
specified data
in the list that are used row-wise to fill up
the 2-factorial treatment groups, i.e. in the order
(0,0), (0,1),..., (0,D[2]), (1,0), ..., (1,D[2]), ..., (D[1],D[2]);
resulting in a (D[1]+1)x(D[2]+1) data array.
To represent trifactorial designs for the evaluation of a
three-compound combination, an object of class cube
can be
created using the function cube
. The data in the treatment
groups are then filled up in the order (0,0,0), ..., (0,0,D[3])
first, then (0,1,0), ..., (0,1,D[3]) and up to
(0,D[2],0), ..., (0,D[2],D[3]). This is the order also for
the values 0, ..., D[1] for the first component group, always
taking the data succesively from the list elements of data
. The
result is a (D[1]+1)x(D[2]+1)x(D[3]+1) data array. Methods for
multiple inference and global tests can
be applied to carpet
and cube
objects.
An object of class carpet
or cube
, respectively, with
the following slots.
data |
The data list specified in the construction. |
D |
Vector of maximum doses specified in the construction. |
n |
Numeric vector of sample sizes in the respective groups. |
Peter Frommolt, University of Cologne peter.frommolt@uni-koeln.de
http://portal.ccg.uni-koeln.de
Frommolt P, Hellmich M (2009): Resampling in multiple-dose factorial designs. Biometrical J, 51(6), pp. 915-31
Hung HMJ, Chi GYH, Lipicky RJ (1993): Testing for the existence of a desirable dose combination. Biometrics 49, pp. 85-94
Hung HMJ (2000): Evaluation of a combination drug with multiple doses in unbalanced factorial design clinical trials. Statistics in Medicine 19, pp. 2079-2087
bifactorial
, mintest
,
margint
, avetest
, maxtest
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