criterium_E_iso: Objective function for E-optimal OED with detection limit

In bioOED: Sensitivity Analysis and Optimum Experiment Design for Microbial Inactivation

Description

Points outside of the allowable area are moved back in time to the detection limit

Usage

criterium_E_iso(x, model, pars, limit)

Arguments

x	a numeric vector of length n defining the design matrix. The first n/2 elements are the time points and the last n/2 are the temperatures of these points.
model	character string defining the inactivation model to use.
pars	list defining the model parameters according to the rules defined in the bioinactivation package.
limit	numerical value describing the maximum number of log-reductions that can be identified in the experiment limit = logDL - logN0, where DL is the detection limit.

Value

Numeric value of the objective function for criterium E, which is a determinant of the FIM.

bioOED documentation built on Aug. 7, 2019, 5:03 p.m.