optimize_refTemp: Optimization of the Reference Temperature

In bioOED: Sensitivity Analysis and Optimum Experiment Design for Microbial Inactivation

Description

Finds the optimum value of the reference temperature which minimizes the correlation between sensitivty functions of the model parameters.

Usage

optimize_refTemp(temp_ref0, lower, upper, inactivation_model, parms,
  temp_profile, parms_fix, n_times = 100)

Arguments

temp_ref0	Initial value of the reference temperature to use for the optimization.
lower	Lower bound for the reference temperature.
upper	Upper bound for the reference temperature.
inactivation_model	Character identifying the inactivation model to use for the calculation.
parms	Numeric vector with the nominal values of the model parameters.
temp_profile	Data frame describing the environmental conditions.
parms_fix	Nominal value of the parameters not considered for the sensitivity.
n_times	Numeric value specifying the nombers of time points where the sensitivity functions will be calculated. 100 by default.

Details

The optimization is made using the optim function. The target for the optimization is the maximization of the determinant of the correlation matrix between parameter sensitivities. The Brent method is used, as it is the recommended one for unidimensional optimization. The parameters z and D/delta cannot be fixed.

Value

The object returned by optim.

bioOED documentation built on Aug. 7, 2019, 5:03 p.m.