Cancer Gene Modules classes for the genes included in
Annotations are taken from the GSEA MSigDB (Molecular Signatures Database) public
The annotations are available in MSigDB C4 (computational gene sets collections) CM
(cancer modules), file: c4.cgn.v3.0.symbols.gmt .
This collection of gene sets is taken from a work published by Segal and colleagues
aimed at the definition of a Cancer Modules Maps. According to the definition of the
authors Cancer Gene Modules are groups of genes that act in concert to carry out a
biological function/process. Cancer Gene Modules have been used to describe expression
profiles in different tumors types in terms of the behavior of modules.
Further information about specific modules can be found at:
It is worth noting that the Cancer Gene Modules annotations contained in bionetdata
covers only the 2033 genes included in
A 2033 x 10 named matrix where rows refer to human gene symbols, columns to 10 Cancer Modules classes.
Original annotations (c4.cm.v3.0.symbols.gmt) are available at:
Segal E., Friedman N., Koller D. and Regev A., A module map showing conditional activity of expression modules in cancer, Nature Genetics, 36(10), 2004
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