Description Details Author(s) References Examples

Implements functions to update Bayesian Predictive Power Computations after not stopping a clinical trial at an interim analysis, whether blinded or unblinded, for a Normally distributed endpoint with known variance, with a prominent example being the hazard ratio.

Package: | bpp |

Type: | Package |

Version: | 1.0.4 |

Date: | 2022-01-13 |

License: | GPL (>=2) |

LazyLoad: | yes |

Kaspar Rufibach (maintainer)

kaspar.rufibach@roche.com

Rufibach, K., Jordan, P., Abt, M. (2016a).
Sequentially Updating the Likelihood of Success of a Phase 3 Pivotal Time-to-Event Trial based on Interim Analyses or External Information.
*J. Biopharm. Stat.*, **26**(2), 191–201.

Rufibach, K., Burger, H.U., Abt, M. (2016b).
Bayesian Predictive Power: Choice of Prior and some Recommendations for its Use as Probability of Success in Drug Development.
*Pharm. Stat.*, **15**, 438–446.

1 | ```
# type ?bpp_1interim for code of all the computations in Rufibach et al (2016a).
``` |

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