to_cpz: Calculates chlorpromazine-equivalent doses

In chlorpromazineR: Convert Antipsychotic Doses to Chlorpromazine Equivalents

Description

Given a data.frame containing doses of antipsychotics to_cpz() converts the doses into the equivalent chlorpromazine (CPZ) doses, using the conversion factors specified in the key.

Usage

to_cpz(
  input_data,
  ap_label,
  dose_label,
  route = "oral",
  key = chlorpromazineR::gardner2010,
  eq_label = "cpz_eq",
  factor_label = "cpz_conv_factor",
  route_label = NULL,
  q_label = NULL
)

Arguments

input_data	data.frame with antipsychotic name and dose data
ap_label	column in x that stores antipsychotic name
dose_label	column in x that stores dose
route	options include "oral", "sai", "lai" or "mixed"
key	source of the conversion factors–defaults to Gardner et al. 2010
eq_label	the name of the column to be created, to save the calculated CPZ-equivalent dose
factor_label	the name of the column to be created to store the conversion factors
route_label	if "mixed" route is specified, provide the column that stores the route information
q_label	if long-acting injectable doses are included, provide the column that stores the injection frequency (days), or only if the doses have already been divided, set q_label = 1.

Details

The default key is gardner2010 which has data for both oral and long-acting antipsychotic medications. See help(gardner2010) for the source reference.

Value

data.frame with new variables storing conversion factor and CPZ-equivalent doses

See Also

Other conversion functions: to_ap()

Examples

participant_ID <- c("P01", "P02", "P03", "P04")
age <- c(42, 29, 30, 60)
antipsychotic <- c("olanzapine", "olanzapine", "quetiapine", "ziprasidone")
dose <- c(10, 12.5, 300, 60)
example_oral <- data.frame(participant_ID, age, antipsychotic, dose, 
                           stringsAsFactors = FALSE)
to_cpz(example_oral, ap_label = "antipsychotic", dose_label = "dose", 
       route = "oral")

Example output

  participant_ID age antipsychotic  dose cpz_conv_factor cpz_eq
1            P01  42    olanzapine  10.0           30.00    300
2            P02  29    olanzapine  12.5           30.00    375
3            P03  30    quetiapine 300.0            0.80    240
4            P04  60   ziprasidone  60.0            3.75    225

chlorpromazineR documentation built on March 14, 2021, 5:07 p.m.