calc_kel_single_tdm: Calculate elimination rate when given a single TDM sample

In clinPK: Clinical Pharmacokinetics Toolkit

Calculate elimination rate when given a single TDM sample

Description

Using iterative k_el calculation, and based on given Volume

Usage

calc_kel_single_tdm(
  dose = 1000,
  V = 50,
  t = 10,
  dv = 10,
  tau = 12,
  t_inf = 1,
  kel_init = 0.1,
  n_iter = 25,
  learn_rate = 0.2
)

Arguments

dose	dose amount
V	volume of distribution
t	time or time after dose
dv	observed value
tau	dosing interval
t_inf	infusion time
kel_init	estimate of elimination rate
n_iter	number of iterations to improve estimate of elimination rate
learn_rate	default is 0.2

Examples

calc_kel_single_tdm(dose = 1000, t = 18)

clinPK documentation built on May 29, 2024, 3:50 a.m.