calc_kgfr: Calculate kinetic GFR

In clinPK: Clinical Pharmacokinetics Toolkit

Calculate kinetic GFR

Description

Calculate the kinetic GFR based on a patients first two serum creatinine measurements. Kinetic GFR may be more predictive of future AKI for patients whose serum creatinine is changing quickly. Briefly, an increase in SCr over the course of a day indicates an effective GFR lower than the most recent SCr measurement may indicate if steadystate is assumed, while a decrease in SCr over a short time indicates a higher effective GFR than the most recent SCr would indicate. There are several ways of approximating maximum theoretical creatinine accumulation rate; here the method used by Pianta et al., (PLoS ONE, 2015) has been implemented.

Usage

calc_kgfr(
  scr1 = NULL,
  scr2 = NULL,
  scr_unit = "mg/dl",
  time_delay = NULL,
  weight = NULL,
  vd = NULL,
  egfr = NULL,
  egfr_method = NULL,
  sex = NULL,
  age = NULL,
  height = NULL,
  ...
)

Arguments

scr1	baseline scr
scr2	second scr measurement
scr_unit	scr unit, defaults to mg/dl
time_delay	time between scr1 and scr2 in hours
weight	patient weight in kg
vd	volume of distribution in L, defaults to 0.6 * weight
egfr	eGFR in ml/min at the time of scr1, or leave blank to call calc_egfr
egfr_method	string, only necessary if egfr is not specified.
sex	string (male or female), only necessary if egfr is not specified.
age	age in years, only necessary if egfr is not specified.
height	in m, necessary only for some egfr calculation methods.
...	further arguments (optional) to be passed to calc_egfr.

Value

kGFR, in ml/min

References

Pianta et al., PLoS ONE (2015)

Examples

calc_kgfr(weight = 100, scr1 = 150, scr2 = 200, scr_unit = 'umol/l',
         time_delay = 24, egfr = 30)
calc_kgfr(weight = 70, scr1 = 350, scr2 = 300, scr_unit = 'umol/l',
          time_delay = 24, egfr_method = 'mdrd', age = 70, sex = 'male')

clinPK documentation built on May 29, 2024, 3:50 a.m.