nform: Helper function to adjust LD parameter r for differential...

In colocPropTest: Proportional Testing for Colocalisation Analysis

Helper function to adjust LD parameter r for differential sample size between snps

Description

Estimate the r between effect estimates at snps which were genotyped on different sets of cases and controls. The adjusted r will be nform(...) * r (where r is the population correlation between snps).

Usage

nform(n0a, n1a, n0b, n1b, n0ab = pmin(n0a, n0b), n1ab = pmin(n1a, n1b))

Arguments

n0a	number of controls with data at snp a
n1a	number of cases with data at snp a
n0b	number of controls with data at snp b
n1b	number of cases with data at snp b
n0ab	number of controls with data at both snps a and b
n1ab	number of cases with data at both snps a and b

Value

proportionality constant that depends on sample size.

colocPropTest documentation built on June 24, 2024, 9:08 a.m.