Estimation, gene selection, and survival prediction based on the compound covariate method under the Cox model with high-dimensional gene expressions. Available are survival data for non-small-cell lung cancer patients with microarrays (Chen et al 2007 New Engl J Med), statistical methods in Emura et al (2012 PLoS ONE) and Emura and Chen (2016 Stat Methods Med Res). Algorithms for generating correlated gene expressions are also available.
Takeshi Emura, Hsuan-Yu Chen, Shigeyuki Matsui, Yi-Hau Chen; Maintainer: Takeshi Emura <[email protected]>
Matsui S (2006). Predicting Survival Outcomes Using Subsets of Significant Genes in Prognostic Marker Studies with Microarrays. BMC Bioinformatics: 7:156.
Chen HY, Yu SL, Chen CH, et al (2007). A Five-gene Signature and Clinical Outcome in Non-small-cell Lung Cancer, N Engl J Med 356: 11-20.
Emura T, Chen YH, Chen HY (2012). Survival Prediction Based on Compound Covariate under Cox Proportional Hazard Models. PLoS ONE 7(10): e47627. doi:10.1371/journal.pone.0047627
Emura T, Chen YH (2016). Gene Selection for Survival Data Under Dependent Censoring: a Copula-based Approach, Stat Methods Med Res 25(No.6): 2840-57
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