Perform assessment of synergy/antagonism for drug combinations based on the Loewe additivity model, following Harbron's approach (Statistics in Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling of the drug interaction index and supports "2-stage" estimation in addition to "1-stage" estimation, including bootstrap-based confidence intervals. The method requires data on the monotherapy responses and the package accommodates both checkerboard and ray designs. Functions are available for graphical exploration of model goodness-of-fit and diagnostics, as well as for synergy/antagonism assessment in 2D and 3D.
|Author||Maxim Nazarov, Nele Goeyvaerts, Chris Harbron (original article and code)|
|Maintainer||Maxim Nazarov <[email protected]>|
|Package repository||View on CRAN|
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