drugCombo: Drug Interaction Modeling Based on Loewe Additivity Following Harbron's Approach

Perform assessment of synergy/antagonism for drug combinations based on the Loewe additivity model, following Harbron's approach (Statistics in Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling of the drug interaction index and supports "2-stage" estimation in addition to "1-stage" estimation, including bootstrap-based confidence intervals. The method requires data on the monotherapy responses and the package accommodates both checkerboard and ray designs. Functions are available for graphical exploration of model goodness-of-fit and diagnostics, as well as for synergy/antagonism assessment in 2D and 3D.

Package details

AuthorMaxim Nazarov, Nele Goeyvaerts, Chris Harbron (original article and code)
MaintainerMaxim Nazarov <maxim.nazarov@openanalytics.eu>
Package repositoryView on CRAN
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drugCombo documentation built on June 7, 2021, 5:08 p.m.