dtl_get_alpha_s: Significance level given a fixed correlation coefficient for...

In dtlcor: Multiplicity Control on Drop-the-Losers Designs

Significance level given a fixed correlation coefficient for the final stage under drop-the-losers (DTL) design

Description

Get significant level alpha_s based on a pre-specified FWER alpha given a fixed correlation coefficient for the final stage (reverse calculation of dtl_tier_the())

Usage

dtl_get_alpha_s(n, t, rho, q, alpha, delta)

Arguments

n	Sample size per arm at DTL look
t	A vector of information fraction of final stage
rho	Fixed correlation coefficient
q	Response rate under the null
alpha	A pre-specified FWER
delta	Least difference to decide superiority of high dose

Value

Significance level alpha_s for the final stage

Examples

# Without interim analysis
dtl_get_alpha_s(n = 80, t = 1, rho = 0.4, q = 0.3, alpha = 0.025, delta = 0.05)

dtlcor documentation built on June 8, 2025, 12:46 p.m.