dtl_tier_sim: Simulated family-wise type I error rate (FWER) given a fixed...

In dtlcor: Multiplicity Control on Drop-the-Losers Designs

Simulated family-wise type I error rate (FWER) given a fixed correlation coefficient under drop-the-losers (DTL) design

Description

Get the simulated FWER alpha given fixed correlation coefficient

Usage

dtl_tier_sim(nsim, n, t, rho, q, alpha_s, sel_g_func = sel_g_func_default, ...)

Arguments

nsim	Number of replicates
n	Sample size per arm at DTL look
t	A vector of information fraction of final stage
rho	Fixed correlation coefficient
q	Response rate under the null
alpha_s	Significance level for the final stage
sel_g_func	Arm-select function. The default function is sel_g_func_default(W_2, W_1, delta). Users can define their own arm-select function. The format of the function must be function_name(W_2, W_1, ...). The return values must be 1 (arm 1 is selected) or 2 (arm 2 is selected) or 0 (stop for futility).
...	Other arguments from sel_g_func.

Value

Simulated FWER alpha

Examples

# Without interim analysis
dtl_tier_sim(nsim = 1000, n = 80, t = 1, rho = 0.4, q = 0.3, 
             alpha_s = 0.025, delta = 0.05)

# With interim analysis
dtl_tier_sim(nsim = 1000, n = 80, t = c(0.5, 1), rho = c(0.4, 0.2), q = 0.3, 
             alpha_s = 0.025, delta = 0.05)

dtlcor documentation built on June 8, 2025, 12:46 p.m.