dtl_tier_the: Theoretical family-wise type I error rate (FWER) given a...

In dtlcor: Multiplicity Control on Drop-the-Losers Designs

Theoretical family-wise type I error rate (FWER) given a fixed correlation coefficient under drop-the-losers (DTL) design

Description

Get the theoretical FWER alpha given fixed correlation coefficient

Usage

dtl_tier_the(n, t, rho, q, alpha_s, delta)

Arguments

n	Sample size per arm at DTL look
t	A vector of information fraction of final stage
rho	Fixed correlation coefficient
q	Response rate under the null
alpha_s	Significance level for the final stage
delta	Least difference to decide superiority of high dose

Value

Theoretical FWER alpha

Examples

# Without interim analysis
dtl_tier_the(n = 80, t = 1, rho = 0.4, q = 0.3, alpha_s = 0.025, delta = 0.05)

# With interim analysis
dtl_tier_the(n = 80, t = c(0.5, 1), rho = c(0.4, 0.2), q = 0.3, alpha_s = 0.025, delta = 0.05)

dtlcor documentation built on June 8, 2025, 12:46 p.m.