Description Usage Arguments Value References Examples
Estimate 50 percent effective dose using different methods.
1 2 3 |
doseSequence |
A sequence of doses given in order |
doseResponse |
A sequence of response results shown in order |
confidence |
The confidence level of interval estimate |
method |
The method used to estimate ED50, there are five methods here, respectively Dixon-Mood, Choi (Choi's Original Turning Point), ModTurPoint (Modified Turning Point), Logistic (Logistic Regression) and Isotonic (Isotonic Regression). The defaut is Dixon-Mood. |
tpCiScale |
The scale level to enlarge the confidence interval estimated by Modified
Turning Point Method. The default value is |
boot.n |
The number of boot process if Logistic method is chosen to estimate ED50. |
A list of estimation result consisting of method of estimation, ED50 estimate, standard error of ED50 estimate, confidence level and estimate of confidence interval.
Dixon, W. J., & Mood, A. M. (1948). A method for obtaining and analyzing sensitivity data. Publications of the American Statistical Association, 43(241), 109-126. Choi, S. C. (1990). Interval estimation of the ld50based on an up-and-down experiment. Biometrics, 46(2), 485-492. Pace, N. L., & Stylianou, M. P. (2007). Advances in and limitations of up-and-down methodology: a precis of clinical use, study design, and dose estimation in anesthesia research. Anesthesiology, 107(1), 144-52.
1 2 3 |
$`Method of Estimation`
[1] "Dixon-Mood"
$`Estimate of ED50`
[1] 3.613333
$`Standard Error of Estimate`
[1] 0.07244503
$`Value of Parameter G`
[1] 0.9716799
$`Confidence Level`
[1] "95%"
$`Lower Bound`
[1] 3.471344
$`Upper Bound`
[1] 3.755323
$`Method of Estimation`
[1] "Logistic Regression"
$`Estimate of ED50`
[1] 3.634308
$`Standard Error of Estimate`
[1] 0.06560869
$`Confidence Level`
[1] "95%"
$`Lower Bound`
[1] 3.500479
$`Upper Bound`
[1] 3.759858
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