summary.emmGrid: Summaries, predictions, intervals, and tests for 'emmGrid'...

In emmeans: Estimated Marginal Means, aka Least-Squares Means

Summaries, predictions, intervals, and tests for emmGrid objects

Description

These are the primary methods for obtaining numerical or tabular results from an emmGrid object. summary.emmGrid is the general function for summarizing emmGrid objects. It also serves as the print method for these objects; so for convenience, summary() arguments may be included in calls to functions such as emmeans and contrast that construct emmGrid objects. Note that by default, summaries for Bayesian models are diverted to hpd.summary.

Usage

## S3 method for class 'emmGrid'
summary(object, infer, level, adjust, by,
  cross.adjust = "none", type, df, calc, null, delta, side, frequentist,
  bias.adjust = get_emm_option("back.bias.adj"), sigma, ...)

## S3 method for class 'emmGrid'
confint(object, parm, level = 0.95, ...)

test(object, null, ...)

## S3 method for class 'emmGrid'
test(object, null = 0, joint = FALSE, verbose = FALSE,
  rows, by, status = FALSE, ...)

## S3 method for class 'emmGrid'
predict(object, type, interval = c("none", "confidence",
  "prediction"), level = 0.95,
  bias.adjust = get_emm_option("back.bias.adj"), sigma, ...)

## S3 method for class 'emmGrid'
as.data.frame(x, row.names = NULL, optional,
  check.names = TRUE, destroy.annotations = FALSE, ...)

## S3 method for class 'summary_emm'
x[..., as.df = FALSE]

Arguments

object	An object of class "emmGrid" (see emmGrid-class)
infer	A vector of one or two logical values. The first determines whether confidence intervals are displayed, and the second determines whether t tests and P values are displayed. If only one value is provided, it is used for both.
level	Numerical value between 0 and 1. Confidence level for confidence intervals, if infer[1] is TRUE.
adjust	Character value naming the method used to adjust p values or confidence limits; or to adjust comparison arrows in plot. See the P-value adjustments section below.
by	Character name(s) of variables to use for grouping into separate tables. This affects the family of tests considered in adjusted P values.
cross.adjust	Character: p-value adjustment method to additionally apply across the by groups. See the section on P-value adjustments for details.
type	Character: type of prediction desired. This only has an effect if there is a known transformation or link function. "response" specifies that the inverse transformation be applied. "mu" (or equivalently, "unlink") is usually the same as "response", but in the case where the model has both a link function and a response transformation, only the link part is back-transformed. Other valid values are "link", "lp", and "linear.predictor"; these are equivalent, and request that results be shown for the linear predictor, with no back-transformation. The default is "link", unless the "predict.type" option is in force; see emm_options, and also the section below on transformations and links.
df	Numeric. If non-missing, a constant number of degrees of freedom to use in constructing confidence intervals and P values (NA specifies asymptotic results).
calc	Named list of character value(s) or formula(s). The expressions in char are evaluated and appended to the summary, just after the df column. The expression may include any names up through df in the summary, any additional names in object@grid (such as .wgt. or .offset.), or any earlier elements of calc.
null	Numeric. Null hypothesis value(s), on the linear-predictor scale, against which estimates are tested. May be a single value used for all, or a numeric vector of length equal to the number of tests in each family (i.e., by group in the displayed table).
delta	Numeric value (on the linear-predictor scale). If zero, ordinary tests of significance are performed. If positive, this specifies a threshold for testing equivalence (using the TOST or two-one-sided-test method), non-inferiority, or non-superiority, depending on side. See Details for how the test statistics are defined.
side	Numeric or character value specifying whether the test is left-tailed (-1, "-", "<", "left", or "nonsuperiority"); right-tailed (1, "+", ">", "right", or "noninferiority"); or two-sided (0, 2, "!=", "two-sided", "both", "equivalence", or "="). See the special section below for more details.
frequentist	Ignored except if a Bayesian model was fitted. If missing or FALSE, the object is passed to hpd.summary. Otherwise, a logical value of TRUE will have it return a frequentist summary.
bias.adjust	Logical value for whether to adjust for bias in back-transforming (type = "response"). This requires a valid value of sigma to exist in the object or be specified.
sigma	Error SD assumed for bias correction (when type = "response" and a transformation is in effect), or for constructing prediction intervals. If not specified, object@misc$sigma is used, and a warning is issued if it is not found or not valid. Note: sigma may be a vector, but be careful that it correctly corresponds (perhaps after recycling) to the order of the reference grid.
...	Optional arguments such as scheffe.rank (see “P-value adjustments”). In confint.emmGrid, predict.emmGrid, and test.emmGrid, these arguments are passed to summary.emmGrid.
parm	(Required argument for confint methods, but not used)
joint	Logical value. If FALSE, the arguments are passed to summary.emmGrid with infer=c(FALSE, TRUE). If joint = TRUE, a joint test of the hypothesis L beta = null is performed, where L is object@linfct and beta is the vector of fixed effects estimated by object@betahat. This will be either an F test or a chi-square (Wald) test depending on whether degrees of freedom are available. See also joint_tests.
verbose	Logical value. If TRUE and joint = TRUE, a table of the effects being tested is printed.
rows	Integer values. The rows of L to be tested in the joint test. If missing, all rows of L are used. If not missing, by variables are ignored.
status	logical. If TRUE, a note column showing status flags (for rank deficiencies and estimability issues) is displayed even when empty. If FALSE, the column is included only if there are such issues.
interval	Type of interval desired (partial matching is allowed): "none" for no intervals, otherwise confidence or prediction intervals with given arguments, via confint.emmGrid. Note: prediction intervals are not available unless the model family is "gaussian".
x	object of the given class
row.names	passed to as.data.frame
optional	required argument, but ignored in as.data.frame.emmGrid
check.names	passed to data.frame
destroy.annotations	Logical value. If FALSE, an object of class summary_emm is returned (which inherits from data.frame), but if displayed, details like confidence levels, P-value adjustments, transformations, etc. are also shown. But unlike the result of summary, the number of digits displayed is obtained from getOption("digits") rather than using the optimal digits algorithm we usually use. Thus, it is formatted more like a regular data frame, but with any annotations and groupings still intact. If TRUE (not recommended), a “plain vanilla” data frame is returned, based on row.names and check.names.
as.df	Logical value. With x[..., as.df = TRUE], the result is object is coerced to a data.frame before the subscripting is applied. With as.df = FALSE, the result is returned as a summary_emm object when possible.

Details

confint.emmGrid is equivalent to summary.emmGrid with infer = c(TRUE, FALSE). The function test.emmGrid, when called with joint = FALSE, is equivalent to summary.emmGrid with infer = c(FALSE, TRUE).

With joint = TRUE, test.emmGrid calculates the Wald test of the hypothesis linfct %*% bhat = null, where linfct and bhat refer to slots in object (possibly subsetted according to by or rows). An error is thrown if any row of linfct is non-estimable. It is permissible for the rows of linfct to be linearly dependent, as long as null == 0, in which case a reduced set of contrasts is tested. Linear dependence and nonzero null cause an error. The returned object has an additional "est.fcns" attribute, which is a list of the linear functions associated with the joint test.

Value

summary.emmGrid, confint.emmGrid, and test.emmGrid return an object of class "summary_emm", which is an extension of data.frame but with a special print method that displays it with custom formatting. For models fitted using MCMC methods, the call is diverted to hpd.summary (with prob set to level, if specified); one may alternatively use general MCMC summarization tools with the results of as.mcmc.

predict returns a vector of predictions for each row of object@grid.

The as.data.frame method returns an object that inherits from "data.frame".

Defaults

The misc slot in object may contain default values for by, calc, infer, level, adjust, type, null, side, and delta. These defaults vary depending on the code that created the object. The update method may be used to change these defaults. In addition, any options set using ‘⁠emm_options(summary = ...)⁠’ will trump those stored in the object's misc slot.

Transformations and links

With type = "response", the transformation assumed can be found in ‘⁠object@misc$tran⁠’, and its label, for the summary is in ‘⁠object@misc$inv.lbl⁠’. Any t or z tests are still performed on the scale of the linear predictor, not the inverse-transformed one. Similarly, confidence intervals are computed on the linear-predictor scale, then inverse-transformed.

Be aware that only univariate transformations and links are supported in this way. Some multivariate transformations are supported by mvregrid.

Bias adjustment when back-transforming

When bias.adjust is TRUE, then back-transformed estimates are adjusted by adding 0.5 h''(u)\sigma^2, where h is the inverse transformation and u is the linear predictor. This is based on a second-order Taylor expansion. There are better or exact adjustments for certain specific cases, and these may be incorporated in future updates.

Note: In certain models, e.g., those with non-gaussian families, sigma is initialized as NA, and so by default, bias adjustment is skipped and a warning is issued. You may override this by specifying a value for sigma. However, with ordinary generalized linear models, bias adjustment is inappropriate and you should not try to do it. With GEEs and GLMMs, you probably should not use sigma(model), and instead you should create an appropriate value using the estimated random effects, e.g., from VarCorr(model). An example is provided in the “transformations” vignette.

P-value adjustments

The adjust argument specifies a multiplicity adjustment for tests or confidence intervals. This adjustment always is applied separately to each table or sub-table that you see in the printed output (see rbind.emmGrid for how to combine tables). If there are non-estimable cases in a by group, those cases are excluded before determining the adjustment; that means there could be different adjustments in different groups.

The valid values of adjust are as follows:

"tukey"

Uses the Studentized range distribution with the number of means in the family. (Available for two-sided cases only.)

"scheffe"

Computes p values from the F distribution, according to the Scheffe critical value of \sqrt{rF(\alpha; r, d)}, where d is the error degrees of freedom and r is the rank of the set of linear functions under consideration. By default, the value of r is computed from object@linfct for each by group; however, if the user specifies an argument matching scheffe.rank, its value will be used instead. Ordinarily, if there are k means involved, then r = k - 1 for a full set of contrasts involving all k means, and r = k for the means themselves. (The Scheffe adjustment is available for two-sided cases only.)

"sidak"

Makes adjustments as if the estimates were independent (a conservative adjustment in many cases).

"bonferroni"

Multiplies p values, or divides significance levels by the number of estimates. This is a conservative adjustment.

"dunnettx"

Uses our ownad hoc approximation to the Dunnett distribution for a family of estimates having pairwise correlations of 0.5 (as is true when comparing treatments with a control with equal sample sizes). The accuracy of the approximation improves with the number of simultaneous estimates, and is much faster than "mvt". (Available for two-sided cases only.)

"mvt"

Uses the multivariate t distribution to assess the probability or critical value for the maximum of k estimates. This method produces the same p values and intervals as the default summary or confint methods to the results of as.glht. In the context of pairwise comparisons or comparisons with a control, this produces “exact” Tukey or Dunnett adjustments, respectively. However, the algorithm (from the mvtnorm package) uses a Monte Carlo method, so results are not exactly repeatable unless the same random-number seed is used (see set.seed). As the family size increases, the required computation time will become noticeable or even intolerable, making the "tukey", "dunnettx", or others more attractive.

"none"

Makes no adjustments to the p values.

For tests, not confidence intervals, the Bonferroni-inequality-based adjustment methods in p.adjust are also available (currently, these include "holm", "hochberg", "hommel", "bonferroni", "BH", "BY", "fdr", and "none"). If a p.adjust.methods method other than "bonferroni" or "none" is specified for confidence limits, the straight Bonferroni adjustment is used instead. Also, if an adjustment method is not appropriate (e.g., using "tukey" with one-sided tests, or with results that are not pairwise comparisons), a more appropriate method (usually "sidak") is substituted.

In some cases, confidence and p-value adjustments are only approximate – especially when the degrees of freedom or standard errors vary greatly within the family of tests. The "mvt" method is always the correct one-step adjustment, but it can be very slow. One may use as.glht with methods in the multcomp package to obtain non-conservative multi-step adjustments to tests.

Warning: Non-estimable cases are included in the family to which adjustments are applied. You may wish to subset the object using the [] operator to work around this problem.

The cross.adjust argument is a way of specifying a multiplicity adjustment across the by groups (otherwise by default, each group is treated as a separate family in regards to multiplicity adjustments). It applies only to p values. Valid options are one of the p.adjust.methods or "sidak". This argument is ignored unless it is other than "none", there is more than one by group, and they are all the same size. Under those conditions, we first use adjust to determine the within-group adjusted p values. Imagine each group's adjusted p values arranged in side-by-side columns, thus forming a matrix with the number of columns equal to the number of by groups. Then we use the cross.adjust method to further adjust the adjusted p values in each row of this matrix. Note that an overall Bonferroni (or Sidak) adjustment is obtainable by specifying both adjust and cross.adjust as "bonferroni" (or "sidak"). However, less conservative (but yet conservative) overall adjustments are available when it is possible to use an “exact” within-group method (e.g., adjust = "tukey" for pairwise comparisons) and cross.adjust as a conservative adjustment. [cross.adjust methods other than "none", "bonferroni", or "sidak" do not seem advisable, but other p.adjust methods are available if you can make sense of them.]

Tests of significance, nonsuperiority, noninferiority, or equivalence

When delta = 0, test statistics are the usual tests of significance. They are of the form ‘⁠(estimate - null)/SE⁠’. Notationally:

Significance

H_0: \theta = \theta_0 versus
H_1: \theta < \theta_0 (left-sided), or
H_1 \theta > \theta_0 (right-sided), or
H_1: \theta \ne \theta_0 (two-sided)
The test statistic is
t = (Q - \theta_0)/SE
where Q is our estimate of \theta; then left, right, or two-sided p values are produced, depending on side.

When delta is positive, the test statistic depends on side as follows.

Left-sided (nonsuperiority)

H_0: \theta \ge \theta_0 + \delta versus H_1: \theta < \theta_0 + \delta
t = (Q - \theta_0 - \delta)/SE
The p value is the lower-tail probability.

Right-sided (noninferiority)

H_0: \theta \le \theta_0 - \delta versus H_1: \theta > \theta_0 - \delta
t = (Q - \theta_0 + \delta)/SE
The p value is the upper-tail probability.

Two-sided (equivalence)

H_0: |\theta - \theta_0| \ge \delta versus H_1: |\theta - \theta_0| < \delta
t = (|Q - \theta_0| - \delta)/SE
The p value is the lower-tail probability.
Note that t is the maximum of t_{nonsup} and -t_{noninf}. This is equivalent to choosing the less significant result in the two-one-sided-test (TOST) procedure.

Non-estimable cases

When the model is rank-deficient, each row x of object's linfct slot is checked for estimability. If sum(x*bhat) is found to be non-estimable, then the string NonEst is displayed for the estimate, and associated statistics are set to NA. The estimability check is performed using the orthonormal basis N in the nbasis slot for the null space of the rows of the model matrix. Estimability fails when ||Nx||^2 / ||x||^2 exceeds tol, which by default is 1e-8. You may change it via emm_options by setting estble.tol to the desired value.

See the warning above that non-estimable cases are still included when determining the family size for P-value adjustments.

Warning about potential misuse of P values

Some in the statistical and scientific community argue that the term “statistical significance” should be completely abandoned, and that criteria such as “p < 0.05” never be used to assess the importance of an effect. These practices can be too misleading and are prone to abuse. See the “basics” vignette for more discussion.

Note

In doing testing and a transformation and/or link is in force, any null and/or delta values specified must always be on the scale of the linear predictor, regardless of the setting for 'type'. If type = "response", the null value displayed in the summary table will be back-transformed from the value supplied by the user. But the displayed delta will not be changed, because there (often) is not a natural way to back-transform it.

When we have type = "response", and bias.adj = TRUE, the null value displayed in the output is both back-transformed and bias-adjusted, leading to a rather non-intuitive-looking null value. However, since the tests themselves are performed on the link scale, this is the response value at which a *P* value of 1 would be obtained.

The default show method for emmGrid objects (with the exception of newly created reference grids) is print(summary()). Thus, with ordinary usage of emmeans and such, it is unnecessary to call summary unless there is a need to specify other than its default options.

If a data frame is needed, summary, confint, and test serve this need. as.data.frame routes to summary by default; calling it with destroy.annotations = TRUE is not recommended for exactly that reason. If you want to see more digits in the output, use print(summary(object), digits = ...); and if you always want to see more digits, use emm_options(opt.digits = FALSE).

See Also

hpd.summary

Examples

warp.lm <- lm(breaks ~ wool * tension, data = warpbreaks)
warp.emm <- emmeans(warp.lm, ~ tension | wool)
warp.emm    # implicitly runs 'summary'

confint(warp.emm, by = NULL, level = .90)

# --------------------------------------------------------------
pigs.lm <- lm(log(conc) ~ source + factor(percent), data = pigs)
pigs.emm <- emmeans(pigs.lm, "percent", type = "response")
summary(pigs.emm)    # (inherits type = "response")
summary(pigs.emm, calc = c(n = ".wgt."))  # Show sample size

# For which percents is EMM non-inferior to 35, based on a 10% threshold?
# Note the test is done on the log scale even though we have type = "response"
test(pigs.emm, null = log(35), delta = log(1.10), side = ">")

con <- contrast(pigs.emm, "consec")
test(con)

test(con, joint = TRUE)

# default Scheffe adjustment - rank = 3
summary(con, infer = c(TRUE, TRUE), adjust = "scheffe")

# Consider as some of many possible contrasts among the six cell means
summary(con, infer = c(TRUE, TRUE), adjust = "scheffe", scheffe.rank = 5)

# Show estimates to more digits
print(test(con), digits = 7)

# --------------------------------------------------------------
# Cross-adjusting P values
prs <- pairs(warp.emm)   # pairwise comparisons of tension, by wool
test(prs, adjust = "tukey", cross.adjust = "bonferroni")

# Same comparisons taken as one big family (more conservative)
test(prs, adjust = "bonferroni", by = NULL)

emmeans documentation built on Oct. 14, 2024, 5:07 p.m.