Estimates both tail areabased false discovery rates (Fdr) as well as local false discovery rates (fdr) for a variety of null models (pvalues, zscores, correlation coefficients, tscores). The proportion of null values and the parameters of the null distribution are adaptively estimated from the data. In addition, the package contains functions for nonparametric density estimation (Grenander estimator), for monotone regression (isotonic regression and antitonic regression with weights), for computing the greatest convex minorant (GCM) and the least concave majorant (LCM), for the halfnormal and correlation distributions, and for computing empirical higher criticism (HC) scores and the corresponding decision threshold.
Package details 


Author  Bernd Klaus and Korbinian Strimmer. 
Maintainer  Korbinian Strimmer <strimmerlab@gmail.com> 
License  GPL (>= 3) 
Version  1.2.17 
URL  https://strimmerlab.github.io/software/fdrtool/ 
Package repository  View on CRAN 
Installation 
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